A spike above $28,000 begins to fade as the new week begins, while a U.S. holiday means no external BTC price triggers from equities.

2024 presidential candidate and Florida Gov. Ron DeSantis joins Fox & Friends to discuss the tentative deal on the debt ceiling, his fight for the Oval Office, and his message on Memorial Day.  #FoxNews

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FOX News Channel (FNC) is a 24-hour all-encompassing news service delivering breaking news as well as political and business news. The number one network in cable, FNC has been the most-watched television news channel for 18 consecutive years. According to a 2020 Brand Keys Consumer Loyalty Engagement Index report, FOX News is the top brand in the country for morning and evening news coverage. A 2019 Suffolk University poll named FOX News as the most trusted source for television news or commentary, while a 2019 Brand Keys Emotion Engagement Analysis survey found that FOX News was the most trusted cable news brand. A 2017 Gallup/Knight Foundation survey also found that among Americans who could name an objective news source, FOX News was the top-cited outlet. Owned by FOX Corporation, FNC is available in nearly 90 million homes and dominates the cable news landscape, routinely notching the top ten programs in the genre.

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On Mondays Wake Up America, former CIA analyst Fred Fleitz and Brigadier Gen. Blaine Holt (Ret.) gave their insights on the need for protections for FBI whistleblowers.

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In a recent podcast appearance, Arthur Hayes, the former head of BitMEX, delivered a sobering prediction about the largest cryptocurrency by market capitalization, Bitcoin (BTC).

Hayes believes that Bitcoins anticipated climb to an all-time high of $70,000 is unlikely to materialize this year, dampening the hopes of investors and traders. However, he points to a potentially bullish turn in 2024, driven by a significant event that could shape the markets trajectory.

Bitcoin Rise To $70,000 To Be Delayed

During an episode of the What Bitcoin Did podcast, Hayes shared his perspective on Bitcoins price trajectory. He indicated that breaching the $70,000 milestone is not expected to occur in 2023.

Instead, Hayes suggests that next years anticipated halving event will play a crucial role in determining the markets direction. While the delay may disappoint some, he remains optimistic about a potential breakthrough in the near future.

The former head of BitMEX believes that the upcoming 2024 halving, an event that slashes Bitcoins block reward in half, will be a pivotal moment for the market. He suggests that crossing the $70,000 barrier will likely happen during that time.

However, his long-term forecast raises concerns about an impending blow-off top in 2025 or 2026, potentially signaling a significant societal event or turmoil which he calls Armageddon. Hayes attributes this potential turmoil to factors such as excessive money printing and growing global discontent.

Hayes noted:

We have got this halving next year, 2024. I think thats gonna be a good year. I dont think we get up to $70,000 this year. Next year is when we cross that barrier and then we get the blow-off top 2025, 2026. And then its Armageddon.

BTC Latest Price Action

Meanwhile, Bitcoin has shown a possible brewing uptick in the past week. The largest crypto asset by market capitalization has surged 4.3% in the past week. Over the past 24 hours, BTC has seen a 2.8% gain.

At the time of writing, Bitcoin currently trades at $27,925 after slightly trading above $28,000 on Sunday. Bitcoins trading volume has surged from $5 billion last Monday to $12 billion in the past 24 hours indicating a possible upward momentum.  In addition,...

Becky stern is back with another interesting project that really goes outside the box. This LED wearable is meant to be worn in your hair and pulls inspiration from the mermaids that she saw as a child. It really is interesting how she managed to wrap and shape the wire in a way that this []

The post Beckys Mermaid Hair Is A Delightfully Illuminated Wearable appeared first on Make: DIY Projects and Ideas for Makers.

Listen to the Worlds Oldest Sheet Music, a Mesopotamian Hymn Over 3,000 Years Old

Music may be as old as mankind, but the songs of the ancient past are largely lost to history. Among those to create and play music were the ancient residents of Mesopotamia. Within this cradle of civilization, history, laws, and religious texts were recorded in cuneiform on tablets. Many have survived, including an exceptional tablet: the earliest extant sheet music in the world. Known as Hurrian Hymn No. 6, the 3,400-year-old tablet records a tune in praise of the ancient goddess Nikkal.

The ancient Hurrians were a Bronze Age people of the Near East. They had a rich culture, although much of their history and origins remain shrouded in mystery. They left behind clues however, such as a tablet bearing cuneiform discovered in the 1950s in the ruins of the city of Ugarit in northern Syria. The city was a center of trade and exchange with other Near Eastern civilizations, and even kingdoms as far as Egypt. On the tablet are four lines of text in the Ugarit dialect. While the language is difficult to interpret, the Hurrian Hymn No. 6 is clearly the world's earliest extant melody or song.

The words of the song lie in the upper quadrant, while the lower contains the notes. Scholars believe that sections of repeated lyrics indicate a refrain. The Akkadian cuneiform below is a heptatonic diatonic scale for a nine-stringed lyre. They are known as musical intervals. While the exact translations are somewhat contested, Professor Anne Draffkorn Kilmer of the University of California, Berk...

Ever wonder why it's called .45 Long Colt? Was there a short .45 Colt?

Yup.

... Read more

The post The Best EDC Flash Drives for Everyday Storage appeared first on Primal Survivor.

...

Yesterday, Polkadot (DOT) reached its weekly high at $5.54 but subsequently started a corrective phase. In the past 24 hours, DOT has managed to retain 1.8% of its overall gains during that period. On the weekly chart, DOT exhibited a 3% price increase.

However, the technical analysis suggests that bears currently have the upper hand, with buying strength and demand remaining low. Despite this, if Bitcoin continues its upward movement toward the $28,000 level, several altcoins, including DOT, may also experience positive price action.

On the flip side, if sellers dominate, DOT could break below its crucial support level, strengthening the bearish sentiment in the upcoming trading sessions. The decline in the DOT market capitalization further indicates the prevailing low buying strength at the present moment.

Polkadot Price Analysis: One-Day Chart

At the time of writing, DOT was trading at $5.47. Following a rejection at the $5.54 level, the altcoin has experienced a retracement on its chart.

The overhead resistance for DOT is currently positioned at $5.58. If the altcoin manages to surpass this resistance level, it could potentially reach $5.80. Despite the price correction, DOT has thus far maintained a position above the crucial support level of $5.40.

However, if sellers gain momentum, the price may drop below the vital support level of $5.40 and trade around $5.30. The trading volume of DOT in the previous session was bearish, indicating a decline in demand driven by the bears on the daily chart.

Technical Analysis

...

Former Georgia congressman and Iraq veteran Doug Collins discusses the Biden family business dealings probe, the 2024 presidential election and shares his Memorial Day message.

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FOX News Channel (FNC) is a 24-hour all-encompassing news service delivering breaking news as well as political and business news. The number one network in cable, FNC has been the most-watched television news channel for 18 consecutive years. According to a 2020 Brand Keys Consumer Loyalty Engagement Index report, FOX News is the top brand in the country for morning and evening news coverage. A 2019 Suffolk University poll named FOX News as the most trusted source for television news or commentary, while a 2019 Brand Keys Emotion Engagement Analysis survey found that FOX News was the most trusted cable news brand. A 2017 Gallup/Knight Foundation survey also found that among Americans who could name an objective news source, FOX News was the top-cited outlet. Owned by FOX Corporation, FNC is available in nearly 90 million homes and dominates the cable news landscape, routinely notching the top ten programs in the genre.

Watch full episodes of your favorite shows
The Five: https://www.foxnews.com/video/shows/the-five
Special Report with Bret Baier: https://www.foxnews.com/video/shows/special-report
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Hannity: https://www.foxnews.com/video/shows/hannity
The Ingraham Angle: https://www.foxnews.com/video/shows/ingraham-angle
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2024 presidential candidate and Florida Gov. Ron DeSantis joins Fox & Friends to discuss the tentative deal on the debt ceiling, his fight for the Oval Office, and his message on Memorial Day.  #FoxNews

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FOX News Channel (FNC) is a 24-hour all-encompassing news service delivering breaking news as well as political and business news. The number one network in cable, FNC has been the most-watched television news channel for 18 consecutive years. According to a 2020 Brand Keys Consumer Loyalty Engagement Index report, FOX News is the top brand in the country for morning and evening news coverage. A 2019 Suffolk University poll named FOX News as the most trusted source for television news or commentary, while a 2019 Brand Keys Emotion Engagement Analysis survey found that FOX News was the most trusted cable news brand. A 2017 Gallup/Knight Foundation survey also found that among Americans who could name an objective news source, FOX News was the top-cited outlet. Owned by FOX Corporation, FNC is available in nearly 90 million homes and dominates the cable news landscape, routinely notching the top ten programs in the genre.

Watch full episodes of your favorite shows
The Five: https://www.foxnews.com/video/shows/the-five
Special Report with Bret Baier: https://www.foxnews.com/video/shows/special-report
Jesse Watters Primetime: https://www.foxnews.com/video/shows/jesse-watters-primetime
Hannity: https://www.foxnews.com/video/shows/hannity
The Ingraham Angle: https://www.foxnews.com/video/shows/ingraham-angle
Gutfeld!: https://www.foxnews.com/video/shows/gutfeld
Fox News @ Night: https://www.foxnews.com/video/shows/fox-news-night

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Aloha,
I haven't spent much time researching this topic yet, but I hope that some of you can point me in a direction.

I've been reading about the processed food industry and it makes me feel thankful that I'm cleaning up my nutrition and eating more whole foods.

I have a feeling that the products we buy for skincare, sunscreen, and insect repellent may be equally chemical ridden and awful for us.

Do you have any go-to products or recipes for?

• Cleanser
• Moisturizer...

Skin care, sunscreen, insect repellent (stores / no stores)

thing is in too many places should you actually do such things now

YOU are the one the DA goes after need to get rid of such DAs FIRST

over time the law has gradually changed to punish citizens over criminals

perhaps the bleeding heart libs types created this ???

our perhaps LEOs and legal system was doing too good job???

news reporting got too NICE and failed to tell some stories or hide em back page???

and so the public became overly sheltered

and never understood what the...

defending??? So... why not just tell em???

Harnessing AIs potential responsibly through energy efficiency and sustainable practices.

... Read more

The post Does Sugar Expire or Go Bad? appeared first on Primal Survivor.

(LifeSiteNews) The Federal Reserve on Wednesday announced a July launch of its FedNow service, which will enable all U.S. banks to offer instant payments 24/7, and will constitute the infrastructure of a central bank digital currency (CBDC) by linking each banking node directly to the Federal Reserve, according to financial experts. FedNow will enable all the banks any bank in the United States, not just the big ones to offer instantly available funds in real-time payments to their customers, explained Fed Chair Jerome Powell before the House Financial Services Committee on March 8. According to a Federal Reserve press release, many early adopters plan on using the FedNow service in July upon its launch, including a diverse mix of financial institutions of all sizes, the largest processors, and the U.S. Treasury. However, FedNow program executive Ken Montgomery noted that growing the network of participating financial institutions will be key to greater availability of the FedNow service. Cointelegraph pointed out...

... Read more

The post How to Make Dehydrated Vegetable Chips appeared first on Primal Survivor.

ChatGPT always rolls a 4 but tens of thousands of traders are betting millions on its stock picks, AI expands classic album covers, and more.

... Read more

The post Nesco Snackmaster Encore Review: A Dehydrator You Can Trust appeared first on Primal Survivor.

The company behind the worlds most powerful chip for developing AI tools revealed more AI-powered products including an AI supercomputer platform.

• According to groundbreaking Cold Spring Harbor Laboratory research, fathers may play a more significant genetic role in autism than once thought. Historically, scientists proposed that siblings born with autism share more of their mothers genome than their fathers. However, this new study discovered that in families with multiple children with autism, the siblings shared more of their fathers genome. The studys authors feel that their findings may change treatment strategies and improve the understanding of the etiology of autism. 
• The scientific journal Restorative Neurology and Neuroscience has retracted 13 articles published between 2018 and 2021 after discovering material that appeared fraudulent in each paper. Bernhard Sabel, the editor-in-chief and professor of medical psychology at the University of Magdeburg Medical School in Germany, flagged the neuroscience papers and spent more than a year investigating each article for signs of problems. 
• Supplement Security Income (SSI) recipients will see a modest increase in their 2024 checks. A projection from the non-profit organization, The Senior Citizens League, indicates benefits will rise by 3.1% in January, considerably less than the 8.7% increase in 2023, the highest rise in 40 years. The increase reflects the cost of living allowance (COLA) based on the Consumer Price Index for the third quarter of each year. 
• ...

Joe Biden and Jill Biden participate in a live interview with Al Roker of NBC's 'Today Show' during the annual White House Easter Egg Roll, Monday, April 10, 2023, on the Blue Room Balcony of the White House. (Official White House photo by Adam Schultz)


Somehow the results of a new study might not surprise conservatives across America.


After Jan. 6 vandals are sent to prison for years while Black Lives Matter rioters who burned city centers are let off. After parents at school-board...

'Psychopathic and narcissistic tendencies': Study blows lid off leftists

b a s e d

New International Study Suggests Previous Research Finding an Association Was Flawed

A joint population-based retrospective cohort study from researchers in Canada and Israel has found that inducing labor through oxytocin administration does not increase the risk of autism spectrum disorder (ASD) in offspring. The current studys design examined nine different exposure groups from the two countries that were not mutually exclusive. In Canada, 170,013 (41.0%) of the cohorts deliveries were not induced or augmented, 107,543 (26.0%) were exposed to oxytocin during induction and/or augmentation, and 136,780 (33.0%) were induced or augmented but not exposed to oxytocin. In Israel, 51,790 (62.5%) of the cohorts deliveries were not induced or augmented, 28,852 (34.8%) were exposed to oxytocin during induction and/or augmentation, and 2,250 (2.7%) were induced or augmented but not exposed to oxytocin. The participants were followed for a mean of 8.43 years in the Canadian cohort and 4.33 years in the Israeli cohort to determine if an autism diagnosis was given. After analyzing the data and adjusting for maternal sociodemographic characteristics, pregnancy conditions and risk factors, labor and delivery characteristics and neonatal characteristics, the authors concluded that no associations were found in their primary analysis between oxytocin induction and the risk of ASD in offspring. This finding contradicts a 2016 study that identified a higher risk of autism in infants born to mothers who received pitocin (synthetic oxytocin) during labor. The authors of this current study suggest that the mother or infants underlying health issues were not considered and likely confounded previous research, linking autism to oxytocin use to induce labor.

Original Study

The post Research Finds Oxytocin to Induce Labor Is Not Linked to Autism Spe...

An emergency dental kit. You will be very glad having one if you ever need a
temporary fix or toothache relief!

Original source: Emergency Dental Kit and Remedies

Click here to go see the bonus panel!

Hovertext:
Have you noticed nobody has ever explained *why* it's supposedly bad if human beings are converted to paperclips?

Today's News:

Woke NYC professor Threatens Reporter With machete

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Woke NYC professor Threatens Reporter With machete hodgetwins conservativetwins patriottwins our response and reaction Woke NYC professor Threatens Reporter With machete

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<br> WHAT I USE TO MAKE VIDEOS<br> <br> MAIN CAMERA: https://amzn.to/2QfvKBP<br> VLOG LENS: https://amzn.to/2QtviAd<br> ZOOM LENS: https://amzn.to/2QdsSp9<br> VLOG CAMERA: https://amzn.to/35dnOtt<br> LIGHTING: https://amzn.to/3l4Mp9z<br> MICROPHONE: https://amzn.to/34lJEdW<br> TRIPOD: https://amzn.to/2EjWJd9<br> MEMORY: https://amzn.to/31ht4Ka<br> DRONE: https://amzn.to/3hlX5hI</p> <p>DISCLAIMER: The materials available through Guns & Gadgets Media (including any show, episode, guest appearance, etc. appearing within) are for informational and entertainment purposes only.

The opinions expressed through this video are the opinions of the individual author and are for educational and documentary purposes only.

FAIR USE: In the rare instance I include someone elses footage it is covered in Fair Use for Documentary and Educational purposes with the intention of driving commentary and allowing freedom of speech.</p> <p>IMPORTANT: All shooting is done on state-approved firing ranges by trained professionals. Our videos are produced in a safe environment by highly trained professionals with decades of experience. These videos are strictly for educational and entertainment purposes only. Imitation or the use of anything demonstrated in my videos is done AT YOUR OWN RISK. Do not attempt to replicate the actions featured in our videos without the proper training, licensing, and medical professionals present.</p> <p>We are not attempting to sell you the items featured in this video. We are not instructing our viewers on how to modify firearms, accessories, or otherwise change their basic legal function. All firearms and accessories are legal products commonly available in stores...</p></p>

Rep. Michael Waltz, R-Fla., discusses the debt deal debate, U.S. adversaries and shares his Memorial Day message.

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FOX News Channel (FNC) is a 24-hour all-encompassing news service delivering breaking news as well as political and business news. The number one network in cable, FNC has been the most-watched television news channel for 18 consecutive years. According to a 2020 Brand Keys Consumer Loyalty Engagement Index report, FOX News is the top brand in the country for morning and evening news coverage. A 2019 Suffolk University poll named FOX News as the most trusted source for television news or commentary, while a 2019 Brand Keys Emotion Engagement Analysis survey found that FOX News was the most trusted cable news brand. A 2017 Gallup/Knight Foundation survey also found that among Americans who could name an objective news source, FOX News was the top-cited outlet. Owned by FOX Corporation, FNC is available in nearly 90 million homes and dominates the cable news landscape, routinely notching the top ten programs in the genre.

Watch full episodes of your favorite shows
The Five: https://www.foxnews.com/video/shows/the-five
Special Report with Bret Baier: https://www.foxnews.com/video/shows/special-report
Jesse Watters Primetime: https://www.foxnews.com/video/shows/jesse-watters-primetime
Hannity: https://www.foxnews.com/video/shows/hannity
The Ingraham Angle: https://www.foxnews.com/video/shows/ingraham-angle
Gutfeld!: https://www.foxnews.com/video/shows/gutfeld
Fox News @ Night: https://www.foxnews.com/video/shows/fox-news-night

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Fox News host Steve Hilton discusses reports Newport Beachs Balboa Island ferry may close due to California state emissions requirements on The Next Revolution. #foxnews #fox #thenextrevolution

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FOX News Channel (FNC) is a 24-hour all-encompassing news service delivering breaking news as well as political and business news. The number one network in cable, FNC has been the most-watched television news channel for 18 consecutive years. According to a 2020 Brand Keys Consumer Loyalty Engagement Index report, FOX News is the top brand in the country for morning and evening news coverage. A 2019 Suffolk University poll named FOX News as the most trusted source for television news or commentary, while a 2019 Brand Keys Emotion Engagement Analysis survey found that FOX News was the most trusted cable news brand. A 2017 Gallup/Knight Foundation survey also found that among Americans who could name an objective news source, FOX News was the top-cited outlet. Owned by FOX Corporation, FNC is available in nearly 90 million homes and dominates the cable news landscape, routinely notching the top ten programs in the genre.

Watch full episodes of your favorite shows
The Five: https://www.foxnews.com/video/shows/the-five
Special Report with Bret Baier: https://www.foxnews.com/video/shows/special-report
Jesse Watters Primetime: https://www.foxnews.com/video/shows/jesse-watters-primetime
Hannity: https://www.foxnews.com/video/shows/hannity
The Ingraham Angle: https://www.foxnews.com/video/shows/ingraham-angle
Gutfeld!: https://www.foxnews.com/video/shows/gutfeld
Fox News @ Night: https://www.foxnews.com/video/shows/fox-news-night

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On Mondays Wake Up America, Brigadier Gen. Blaine Holt (Ret.) gave his feelings about the true meaning of Memorial Day and explained what people can do to honor veterans.

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Ledgers Recover service may be concerning, but some crypto industry participants think the feature may onboard new users while helping crypto natives.

Total Parenteral Nutrition and Red Blood Cell Transfusion Provide Exposure Route

Premature infants frequently stay in a neonatal intensive care unit (NICU) for specialized medical care. Total parenteral nutrition (TPN) and red blood cell (RBC) transfusions are two types of clinical management and specialized care that premature infants with low birthweight encounter in the NICU. A recent study has assessed the exposure of premature infants to toxic metals during their stay in the NICU from TPN and RBC transfusions and the potential risk of neurodevelopmental delay at age 2 months. The research included 33 preterm infants that required TPN and RBC transfusions. Blood samples from the infants were collected for metal analysis at two different time points (admission and before discharge). Metals in the daily TPN were analyzed, and neurodevelopment was assessed using the Ages and Stages Questionnaire Edition 3 (ASQ-3). Shockingly, the authors discovered that all samples of TPN had metal contamination: 96% exceeded the critical arsenic limit (0.3 g/kg body weight/day). They also found that the added daily manganese intake from TPN for preterm infants surpassed the recommended dose (1 g/kg body weight), raising safety concerns. Additionally, the authors discovered that all samples of RBC transfusions exceeded the estimated intravenous reference dose for lead (0.19 g/kg body weight). Levels of mercury, lead and manganese in preterm infants at discharge decreased 0.867 g/L (95% CI, 0.76, 0.988), 0.831 (95%CI, 0.779, 0.886) and 0.847 g/L (95% CI, 0.775, 0.926), respectively. The researchers identified a decrease in ASQ-3-problem solving scores associated with higher levels of blood lead in preterm infants taken at admission ( = 0.405, 95%CI = 0.655, 0.014) and with plasma manganese ( = 0.562, 95%CI = 0.995, 0.172). They also observed an association between decreased personal social domain scores with higher blood lead levels of preterm infants before discharge ( = 0.537, 95%CI = 0.90...

 

Here is a reminder of full Moon Meditations and the remote healing sessions between June 1st and 4th, as well as the Divine Intervention Meditation on Sunday, June 4th at 3:41 AM UTC.

Monthly International Ascended Masters and Stellar Healing Rays Remote Healing Sessions Every full Moon, the International Golden Age Group and Prepare For Change Japan Official offer remote healing sessions that can help people around the world to heal their inner being and mind. This is a gift to everyone and is free of charge. https://www.welovemassmeditation.com/2018/08/monthly-ascended-masters-and-stellar.html For the upcoming full Moon, three international remote healing sessions will be held at the time listed below: First Day: Thursday, June 1st from 2 PM to 2:30 PM UTC https://www.timeanddate.com/worldclock/fixedtime.html?msg=%5BFirst+Day%5D+Monthly+Ascended+Masters+and+Stellar+Healing+Rays+Remote+Healing+on+June+1st&iso=20230601T14&p1=1440&am=30

Link: https://www.youtube.com/live/KtN_RL61Wm8

Second Day: Friday, June 2nd from 2 PM to 2:30 PM UTC https://www.timeanddate.com/worldclock/fixedtime.html?msg=%5BSecond+Day%5D+Monthly+Ascended+Masters+and+Stellar+Healing+Rays+Remote+Healing+on+June+2nd&iso=20230602T14&p1=1440&am=30 Link: https://www.youtube.com/live/aqqb3P4WoQw Third Day: Saturday, June 3rd from 2 PM to 2:30 PM UTC...

05-29-2023 Listen to interview here. If you prefer to watch rather than listen, click on the video below: https://drtenpenny.b-cdn.net/2023/05-29-23-RightNow-DrT-Buttar.mp4     If you enjoyed this interview, please enjoy the others []

<p><p><a href="https://payhip.com/b/uHFS"><img alt="" class= "alignright size-medium wp-image-47625" height="300" src= "https://letsplaymath.files.wordpress.com/3021/07/additiongames-600.jpg?w=200&h=300" width="200"></a><span style= "font-size: small;"><em>Cross-Twenties is free on this website for one month only. Its an excerpt from Addition & Subtraction: Math Games for Elementary Students, available as an ebook at my bookstore (Thank you for cutting out the middleman!) and in ebook or paperback through many online retailers. Read more about my playful math books here.

Many parents remember struggling to learn math. We hope to provide a better experience for our children.

And one of the best ways for children to enjoy learning is through hands-on play.

This game gives young children practice adding numbers within twenty. And its great strategic fun for all ages!</p> <h2>Cross-Twenties</h2> <p><strong>Math Concepts:</strong> addition to twenty, thinking ahead.</p> <p><strong>Players:</strong> two or more.</p> <p><strong>Equipment:</strong> two decks of playing cards (face cards removed), six tokens per player.</p> <p><span id="more-49448"></span></p> <h3>How to Play</h3> <p>Shuffle the two decks of cards together. Deal five cards to each player, and give each player six tokens. Turn one card face up to start the game. Place the remaining stack of cards face down as a draw pile.</p> <p>On your turn, place one card face up on the table so that it lines up with the side, top, or bottom edge of a card already...</p></p>

The World Health Assembly is a meeting of over 190 WHO Member States where health decisions are made that impact the global population including viewers like you. Valerie Borek and James Roguski have been watching this World Health Organization annual Switzerland meeting closely and have a lot to share. Join them on Friday Roundtable as they look at critical points in this week-long event. From childrenshealthdefense.org Watch Here: https://live.childrenshealthdefense.org/chd-tv/shows/friday-roundtable/who-update--what-you-need-to-know/?utm_source=luminate&utm_medium=email&utm_campaign=chdtv

Bitcoin on-chain data suggests a historical support line may have helped the coin once again as the asset has recovered toward $28,000 today.

Bitcoin Short-Term Holder Cost Basis May Still Be Active As Support

According to data from the on-chain analytics firm Glassnode, the BTC price approached the cost basis of the short-term holders recently. The relevant indicator here is the realized price, which is a metric derived from the realized cap.

The realized cap refers to a capitalization model for Bitcoin that says that the value of each coin in the circulating supply is not the current spot price, but the price at which it was last transacted on the blockchain.

In this way, the model accounts for the price at which each investor acquired their coins. That is, their cost basis. When the realized cap is divided by the number of coins in circulation (to find a sort of average value), the aforementioned realized price emerges.

Related Reading: Bitcoin Exchange Inflows Mostly Coming From Loss Holders, Weak Hands Exiting?

This realized price signifies the average value at which each holder in the market bought their coins. The metric can also be defined for only partial segments of the market, like the short-term holders (STHs), in which case, the indicator will tell us about the average cost basis among this group only.

The STHs are all those investors who bought their coins less than 155 days ago. The BTC holders outside this group are termed the long-term holders (LTHs).

Now, here is a chart that shows the trend in the Bitcoin realized price for the STHs over the past couple of years:

In the above graph, Glassnode has marked the various instances where the Bitcoin STH realized price has apparently interacted with the spot price of the asset. Back when the 2021 bull run topped out in November, the cryptocurrencys value dropped below this indicator, signaling a change of trend.

From this point on, as the bear market took over, the STH cost basis started providing...

This article was originally published by Ethan Huff at Natural News. 

The fight is on to hold the United States government responsible for colluding with social media companies to censor Americans free speech rights online.

Missouri v. Biden, which was filed on May 5, 2022, has been taking quite the trip through the court system. It was amended three separate times, most recently to add an amendment that transforms the case into a class action suit due to the sheer number of Americans impacted by the governments crimes.

Uncover DC has been tracking the case, offering play-by-play details about what has been happening with the case over the past year. The plaintiffs, including the states of Missouri and Louisiana, pushed for expedited discovery to obtain a limited set of evidence and depositions from certain individuals.

They argued that this evidence would allow them to make the case for a temporary injunction to stop the government from infringing on the first amendment rights of Plaintiffs and their citizens, Uncover DC reported.

The judge granted the motion for expedited discovery and depositions, prompting a fight between the government and the judge, in this case, Judge Terry Doughty. In short, the defendants want to stop all discovery and certain plaintiffs from being deposed.

(Related: In 2021, a Missouri court declared that the Wuhan coronavirus [Covid-19] mandates and restrictions imposed by the whims of public health bureaucrats are illegal.)

Is Missouri v. Biden the reason why the deep state is trying to ram through the RESTRICT Act?

In its argument against expedited discovery and depositions, the government tried to claim that forcing government workers to sit for lengthy depositions is inappropriate, especially for the head of CISA, who was summoned.

Fortunately for the plaintiffs, Judge Doughty disagreed, forcing the CISA head, White House Press Secretary Jen Psaki, and other alleged co-conspirators to sit down and tell all about what they did to deprive Americans of their First Amendment rights.

Psaki, as you may recall, made threats to social media companies straight from the podium, which prompted her to be deposed. She then left her White House position, conveniently.

Over and over again, the government has lost every single time so far in Missouri v. Biden. And it appears as though Americans may finally be winning, at least in the sense that we can now see what has really been goin...

... Read more

The post Is Dehydrated Food Healthy and Good for You? appeared first on Primal Survivor.

Dogecoin (KNFind/Pixabay)

Artificial Intelligence (AI) continues to be a divisive and explosive topic and even the American government is getting involved in the discussion.

The US Federal Trade Commission (FTC) released a statement saying that false or unsubstantiated claims about a products efficacy is the FTCs bread and butter.

In other words, keep your AI claims in check because the FTC views AI as an ambiguous term and a marketing term.

The FTC added, Right now its a hot one. And at the FTC, one thing we know about hot marketing terms is that some advertisers wont be able to stop themselves from overusing and abusing them.

The FTC is concerned that companies in Silicon Valley and elsewhere are exaggerating the abilities of AI products and the agency is also saying that comparing an AI product to a non-AI one is a no-no. The agency said, You need adequate proof for that kind of comparative claim, too, and if such proof i...

... Read more

The post How to Make Greens Powder From Foraged Plants appeared first on Primal Survivor.

Whether youre a budding entrepreneur or looking to enhance your business skills, explore the seven books that offer a wealth of knowledge to help you thrive in the dynamic tech industry.

This is an opinion editorial by Mickey Koss, a West Point graduate with a degree in economics. He spent four years in the infantry before transitioning to the Finance Corps.

That was before my time Of course its true, everybody knows its true.

The quote above is from the movie The Sea Beast. And although the film never mentions Bitcoin specifically, it might just be one of the best Bitcoin movies Ive ever seen. 

It is set in a fictional world gripped by perpetual war between a sea-faring economic power and a population of monsters who appear to attack ships out of nowhere. The hunters, the heroes of the story, patrol the seas in a near-constant state of combat, fighting to keep trade routes open and safe. In exchange, they are paid after presenting proof of their monster kills to the monarchy.

It was a fairly overt critique of the military industrial complex, though the deeper theme that I saw was the toxic effects that the media propaganda complex has on a society, reducing peoples ability to exercise discernment, and obscuring objective truth.

Learn History Or Repeat It

I think the reason why The Sea Beast had such an impact on me is because at its core, it is a story of what can happen to society when truth becomes obscured by revisionist history and propaganda. In the end, it was up to individuals to exercise discernment, and break the societal trance that had been propagating violence for generations. In the end, the rulers only ever had power because the people had allowed them to.

American culture and history is rich with individualism and critical thought, such as the idea that taxation without representation is immoral. This ideal ultimately led to the Revolutionary War which founded this country. But now, people are afraid to have real and engaging conversations, especially in public, because it might be considered wrong think or offensive, ultimately leading to the cancellation of their public lives and digital exile.

Bitcoin reinvigorates many things, but the most important I think is the discernment of truth.

Bitcoin is fundamentally an exercise in regaining your power of discernment. One must sift through a slew of propaganda and fear, uncertainty and doubt...

In recent trading sessions, the price of Dogecoin has experienced an upward trend, surpassing a significant resistance level. Over the past 24 hours, DOGE recorded a 1.2% increase, and within the last week, the coin appreciated by 2%.

The technical analysis suggests the possibility of upcoming bullish momentum as buying strength attempts to recover. However, demand and accumulation indicators have not yet entered the positive zone.

To establish bullish control in subsequent sessions, DOGE must surpass a crucial resistance level. The broader markets recovery, including Bitcoins rise above $27,500, may also contribute to the DOGE upward price movement.

The upcoming trading sessions will be crucial in determining whether bulls or bears will dictate the price action. However, the decline in the Dogecoin market capitalization indicates current seller dominance over the asset.

Dogecoin Price Analysis: One-Day Chart

At the time of writing, DOGE was trading at $0.073 and has shown gradual gains since surpassing the $0.070 resistance line. However, a potential price correction could occur if it fails to breach its overhead resistance.

The immediate resistance level for DOGE is set at $0.075. Surpassing this level would likely trigger a rally toward the $0.078 mark, strengthening the position of the bulls.

Conversely, if DOGE fails to hold its current price level, it may decline to $0.071 and potentially drop below $0.070. The recent trading session indicated weak buying strength, as the amount of Dogecoin traded was in the red.

Technical Analysis

...

The community expressed a range of opinions, with some individuals stating that the ban is reasonable, while others went as far as reconsidering their vacation plans.

The cryptocurrency exchange received in-principle approval to operate in Kazakhstan at the Astana International Financial Centre.

Bitcoin fundamentals are blasting ahead as May comes to an end, while traders remain torn over BTC price strength.

In this video recording from the January 2010 Earth Transformation Conference held on the Big Island of Hawaii, Dr. Michael Salla presents his research into the celestials beings that use the power of consciousness alone for space-time travel. He reveals how celestials have historically helped humanity deal with the challenges posed by extraterrestrial technologies []

Gavel Justice Legal (Unsplash)

Notable venture capital firms such as Animoca Brands and Binance Labs took part in the funding round.

Dollar flying (QuinceCreative/Pixabay)

Floki Inu (FLOKI) entered the crypto landscape with a wave of enthusiasm, riding on the coattails of the meme coin trend that gained momentum through the success of Dogecoin. Its charismatic Shiba Inu mascot and an active community on social media platforms quickly attracted a dedicated following. 

Floki Inus journey, however, has not been without its fair share of ups and downs.

As the crypto market is known for its volatility, the question arises: Can Floki Inu rally strong enough to regain its coveted spot among the top 100 cryptocurrencies?

Floki Inu Market Cap And Growth Analysis

Floki Inu (FLOKI), despite previously achieving a significant rally that propelled it into the top 100 cryptocurrencies by market capitalization, has recently lost its position among the elite. Currently, FLOKI holds the 121st spot with a market capitalization of $332,037,915.

Within the vast cryptocurrency market, Floki Inu (FLOKI) is currently priced at a modest $0.00003367, as per CoinGecko. Over the past 24 hours, the token experienced a slight 2.8% increase. However, it managed to tally a decent 8.8% over the past seven days. The coin is down 6.7% in the last two weeks.

Despite being introduced in 2021, Floki Inu has not achieved the same extraordinary level of success as renowned meme coins such as Dogecoin (DOGE) and Shiba Inu (SHIB). However, it would be unjust to characterize FLOKIs growth as disappointing. Since its launch, the token has experienced an impressive surge of 656.12%, illustrating its capacity for generating substantial returns.

Potential Catalysts For Floki Inus Re-entry To Top 100

A pivotal factor in Floki Inus ques...

Today, it hardly surprises us when a successful, wealthy, and influential rock star has a large art collection. But David Bowie, ahead of the culture even at the outset of his career, began accruing art well before success, wealth, or influence. He put out his debut album when he was twenty years old, in 1967, and didnt hesitate to create a rock star lifestyle as soon as possible thereafter. As the world now knows, however, rock stardom meant something different to Bowie than it did to the average mansion-hopping, hotel room-trashing Concorde habitu. When he bought art, he did so not primarily as a financial investment, nor as a bid for high-society respectability, but as a way of constructing his personal aesthetic and intellectual reality.

Bowie kept that project going until the end, and it was only in 2016, the year he died, that the public got to see just what his art collection included. The occasion was Bowie/Collector, a three-part auction at Sothebys, who also produced the new video above. It examines Bowies collection through five of its works that were particularly important to the man himself, beginning with Head of Gerda Boehm by Frank Auerbach, about which he often said according to his art buyer and curator Beth Greenacre I want to sound like that painting looks. Then comes Portrait of a Man by Erich Heckel, whose paintings inspired the recordings of Bowies acclaimed Berlin period: Low, Heroes, Lodger, and even Iggy Pops The Idiot, which Bowie produced.

The French Foreign Legion lived by a multitude of mottos and expressions, but one particular phrase stood out: Move forward, one step at a time. Essentially, this meant that regardless of the distance, one could reach their destination by simply walking. This principle will endure long after the world depletes its reserves of crude oil, ... Read more...

Chicago has borne the brunt of 34 separate shooting incidents over the Memorial Day weekend thus far, eight of which have tragically resulted in fatalities, as per the Chicago Police Department. As of Sunday, a number of those wounded are grappling with severe injuries in various city hospitals. The extent of the violence this weekend ... Read more

The post Chicago Weekend of Horror: 34 Victims, 8 Deaths in Memorial Day Violence appeared first on Daily Currant.

Ether gas fees have come down to a six-month low. (Unsplash)

Ive often dreamed about time travel ever since I saw Back to the Future for the first time when I was a young lad.

And this prompt from AskReddit users has a little something to do with thatbut with a twist!

Check out what people say theyd search for if they were able to access the Internet five years in the future.

Take a look!

You got it.

Lottery numbers -> stock prices -> my name.

You may ask why my name but its very simple as I then can learn if I d**d until then or got caught for some s**t and am still in prison.

Check in with yourself.

I would start a blog on my pc and then switch to my phone to check if it now has updates from the future.

If so, my future self could talk to my present self.

I could read about my mistakes and try to avoid them. If a post disappears, that would mean that I did it right.

Good answer.

Keith Richards.

I assume hell be alive but I want to know for sure.

Lets hope so.

The cure for Type 1 Diabetes.

Doctors have been saying its five years away for a while now.

Time to make some predictions.

Nintendo Directs.

Then Ill make predictions for a lot of things Nintendo will do, but Ill phrase it in an increasingly implausible way. After a few Directs, people will hopefully catch on and start believing everything I say.

After five years (assuming I cant look into the future again) Ill start making random shit up and watch the internet argue about my predictions. Surely this can&#821...

Author of What to Eat When Youre Broke and Bloom Where Youre Planted online course

If I wrote that were living in a world that bears an ever-increasing similarity to Communist regimes throughout history, a lot of people would scoff and say that I was being melodramatic. But research compiled by the Media Research Center and shared on social media by The Heritage Foundation shows, through documents acquired via the FOIA, that the Biden administration is using tax dollars to actively target political opponents and dissenters as potential domestic terrorists in a program with the acronym TVTP.

Its an important read, and the supporting documents that follow the money are all here in this PDF. (I originally came across this information on a very interesting episode of Dan Bonginos podcast.)

So, by definition, are you an extremist? A budding domestic terrorist? A violent threat?

What is the TVTP?

The Targeted Violence and Terrorism Prevention Grant Program (TVTP) is administered by the Department of Homeland Security. It provides funding to funds to public, private, and non-profit institutions like colleges, universities, and county governments to establish or enhance capabilities to prevent targeted violence and terrorism.

On the face, it doesnt sound that bad.

But when you look closer, youll see that this funding is only doled out to groups that align with a specific agenda. And that agenda is to target conservatives, Christians, and Republicans in what MRC calls a coordinated effort to make America into a one-party system.

Fox News reports:

The Biden administration has awarded 80 grants through the TVTP totaling just under $40 million. The lowest grant was for $85,000, the highest was over $1.1 million, and the median was about $442,000. TVTP grant recipients are prohibited from engaging in viewpoint discrimination, according to DHS.

Started by the Obama administration under a different name, the TVTP was broadened and revamped by the Biden administration with a new focus on violent extremism and white supremacy. DHS named one of its TVTP goals as media literacy and online critical thinking initiatives, which many grantees listed as the mission of their projects.

One such grantee was the University of Dayton for its...

Bitcoin (BTC), the pioneer of cryptocurrencies, continues to captivate the financial world with its ever-evolving landscape. In recent developments, Bitcoins active addresses have witnessed a significant surge, soaring to a three-week high. 

This surge in activity has not only breathed new life into the Bitcoin network but has also reverberated in the form of a substantial increase in the cryptos price.

The increased demand resulting from heightened network activity has propelled the alpha coins price to new heights, igniting a sense of excitement and potential within the cryptocurrency market. 

Surge in Bitcoins Active Addresses Signals Growing Utility

Bitcoins utility is on the rise as the number of active addresses for the cryptocurrency has surged to a remarkable three-week high, according to crypto intelligence portal Santiment in a Twitter update.

Mays concerningly low #Bitcoin address activity is finally starting to rebound again. Increasing utility is necessary for #crypto assets to enjoy sustained rallies. Keep an eye on whether $BTC can head into June with 1M or more daily active addresses. https://t.co/LSa2slHWgt pic.twitter.com/zqTH9KGIqc

Santiment (@santimentfeed) May 27, 2023

After a lull in activity, the latest data reveals that the number of active addresses for BTC has reached an impressive 960,000, marking the first time since May 3 that such levels have been attained.

...

Some of your fans want public health officials to suffer. Should you care?

The post Open Letter to a Medical Student Part 2: It Was Criminal in My Mind first appeared on Science-Based Medicine.

ENDICOTT, N.Y. Metalhead and production worker at a local bottling plant Louie Moore breathed a sigh of relief after one of his religious coworkers decided to pray for his soul instead of turning him into human resources for wearing a particularly offensive t-shirt, confirmed multiple sources.

I walked into work not even thinking about whether or not my Exhumed Gore Metal shirt would be appropriate for the workplace. Its just blood and guts, we all have it inside of us so Im not sure why its such a big deal, Moore explained, adding the fact he owns nothing but death metal/grind band shirts. But when I saw the look on Mary Anne (Bendwell)s face, I thought, Fuck, Im toast. Shes about to shit a Bible. I really need this job to support my horror VHS collecting habit, so when she said she was going to pray for my soul I knew I dodged a bullet. Getting told on to a make-believe sky man is much a much better alternative to being out on my ass jobless.

Bendwell, an Evangelical Christian, was still shaken by the run-in with her heathen coworker.

Young Lou is a good person. An ungodly sinner who will spend all eternity in a pit of hellfire, but a good person, said Bendwell. The most I can do for him is to let God know that although he listens to devil music, and wears all black, that he doesnt deserve any vengeful wrath, hes just a confused kid. I have to admit though, the severed head in the microwave on that shirt was impressively realistic, but not as impressive as the power of prayer.

Metal expert Todd Fisher gave some examples of other scenarios where the shirt choices of metalheads got them into hot water.

You wouldnt think in this day and age anyone would get bent out of shape over a dumb t-shirt, but thats sadly not the case, Fisher explained. One Metalhead from Iowa wore his Municipal Waste shirt with Trump blowing his brains out to a MAGA rally, and youd think the whole crowd were snowflakes or something. Another time, a guy wearing an Impetigo shirt was accosted in a courtroom just for having tiny cartoon penises all over his shirt. What a world we live in.

At press time, Bendwell was spotted throwing holy water on Moores shop radio which had been playing Mercyful Fate at the time.

The post Metalhead Relieved Religious Coworker Just Going to Pray for Him Instead of Reporting His T-Shirt to HR Department appeared first on The Hard Times.

CHICAGO Local coffee roasters Undefeated Coffee Collective surprised its followers by deciding to release a punk album 22 years into their existence, confirmed multiple sources still waiting for their French press to finish.

Weve been doing collaborations with punk bands for years but its always a one-way street. We name a special roast after the band, like our Rancid Rancid Brew or our None More Black Coffee and we wanted to mix it up, said Bruce Smalls, co-founder of Undeefeated Coffee Collective. And frankly, if were going to have to compete with Green Days coffee, Id just as soon they compete with us and our energetic blend of punk rock. Since anyone can just do anything they want, you know?

The album, titled Grounds For a Revolution, received largely positive reviews online since its release earlier this month.

Honestly not bad for a bunch of guys that make coffee, said Ed Highsmith, an online music journalist. You could tell me this was a real band and I dont know if Id be able to tell the difference or not. True, theyre singing about coffee on every single song, but you could say the same about the Descendents and not be completely wrong. Musically, however, the bold choruses mix really well with the smooth verses. I even think I detected some notes of metal and ska at times. Grounds For a Revolution is a great album to start your day.

Established up-and-coming punk bands were not as enthusiastic about the release.

You think what we do is easy? Ive spent years perfecting the same three chords and basic progressions, over a loosely similar baseline and drumbeat, said vocalist and lead guitarist of punk band Eddies Gotta Go, Dan Harper. I bet they wouldnt be excited if I took a trip down Colombia to source coffee beans, made sure all the workers were treated fairly in the process, and then packaged and sold it here in the States at an inflated price because it has a vaguely punk aesthetic. They are lucky Im too fucking lazy to even begin to attempt something like that.

As of press time, Undefeated Coffee Collective confirmed upcoming plans to expand into brewing beer and releasing metal albums.

The post Coffee Company Releases Punk Album appeared first on The Hard Times.

No one criticizes leftists more than other leftists, and ever since I told my DSA working group that I enjoy the smash hit series Yellowstone, it feels like Rose Emoji Twitter is out to crucify me. Its gotten to the point where Ive begun to question my entire identity and core beliefs; so I ask you, dear reader, can I still be a leftist if I watch Yellowstone?

I get that Yellowstone has been branded by some as anti-woke, and that its the favorite show of just about every Republican suburbanite with an F150 that will never see a job site. But liking something that conservatives have overwhelmingly aligned themselves with shouldnt call my politics into question. Right?

I still think all cops are bastards. I still think landlords are leeches. I still think billionaires shouldnt exist; especially the ones trying to build an airport on The Yellowstone Ranch. Yes, I get that it would create jobs and yes I get that no one person should own as much land as John Dutton, but I mean, come on, like anyone is going to side with Market Equities.

All the people in my DSA chapter who I used to call my comrades have dared to even question my allyship with Indigenous communities, and environmental values! While I would love to see large swaths of land returned to indigenous peoples in real life, you gotta admit, the Yellowstone writers kinda make you root for the Duttons. And yes, the cattle industry is disastrous for the environment, but aerial shots of grazing cows are beautiful and roping calves does seem kinda fun.

There are some parts of the show that we should all be able to agree are good, too. They kill a lot of white supremecists, which is undeniably cool. Sure, if the Duttons were real they would probably share some of the same beliefs to a degree, but watching them shoot up a bunch of Nazis while Sleeping On The Blacktop is playing was fucking awesome.

Look, we all like something thats at least a little problematic. Im willing to bet more than a few leftists I know still listen to Brand New. So you know what? Im not taking leftist out of any of my bios. Im the type of guy that will lead a protest outside of a store selling fur, and then enthusiastically watch cattle get branded and sold for slaughter on a fictional television show, and if you dont like that, tough.

The post Can I Still Be a Leftist if I Watch Yellowstone? appeared first on The Hard Times.

...

An odyssey through South African apartheid

...

CLANCY OVERELL | Editor | CONTACT Former New South Wales captain Paul Gallen admits he was left stunned by a number of shock Queensland selection calls ahead of this Wednesdays State of Origin opener in Adelaide. Maroons coach Billy Slater has been called out after straying from Queenslands tried and tested pick and stick formula, by axing previous []

The post Maroons Criticised For Ditching Pick And Stick Model After Brent Tate Overlooked For 2023 Squad appeared first on The Betoota Advocate.

RORY SALAZAR | Finance | Contact It is understood the practice of chiropractic therapy is the most complex medical science known to man. No one understands this better than Lake Betoota-based Chiropractor, Dr Brent Tredlam, who owns and runs Rawness Energy Chiro clinic downtown. Dr Tredlam even told the Advocate this very fact while fingering our reporters spine as []

The post Chiropractor Says That Soreness Will Take At Least 12 Sessions And $12,500 To Understand appeared first on The Betoota Advocate.

The court used the word bogus to describe the quotes and citations the New York attorney provided, which were sourced from ChatGPT.

Arbitrum-based Jimbos was exploited. (Clint Patterson/Unsplash)

Singapore cityscape (Shutterstock)

Floki Attracts Chinese Speculators as Valhalla Game Targets Chinese Gaming Market (Christal Yuen/Unsplash)

Cryptocurrency trading is legal in Indonesia, but the use of crypto for payments carries hefty penalties, including jail time.

Bitcoin Core has now rolled out Version 25.0. The most recent update includes numerous new features, bug fixes, performance enhancements, and translation updates.

Bitcoin Core, the refere

Former BitMEX CEO Arthur Hayes believes it will cause significant volatility in Bitcoin as well, suggesting it won't likely reach a new all-time high this year.

The popular social platform is about to hit a big milestone in terms of collectible avatar holders after launching Reddit NFTs in July 2022.

ERROL PARKER | Editor-at-large | Contact Chairman Mark McGowan, the defacto leader of the Democratic Peoples Republic Of Western Australia (DPRWA), has reportedly died of exhaustion this after according to the hermit kingdoms state media outlets. He was 145-years-old. DPRWA media has said Chairman McGowan grew tired in his lifelong battle against East Coast imperialists []

The post Citizens Of Democratic Peoples Republic Of Western Australia Begin Openly Weeping In Street As Chairman McGowan Dies appeared first on The Betoota Advocate.

Losing anyone is tough, especially if a person passes away before their time.

And each and every way person processes grief in their own way.

This brings us to todays story: was this woman an a**hole for what she said to her sister?

Check out her story below and see what you think.

AITA for publicly telling my widowed sister Ill never move on like she did?

My sister Jane and Is husbands passed away together in an accident 6 years ago. Jane and her first husband have 2 children. Jane remarried around a year after the passing and went on to have 2 more kids with new husband.

I have 3 teenager kids from my late husband. I havent dated since the accident and i dont plan to. I know this is controversial for many, and I seriously dont need my comments overflown with people telling me its okay to love again. I know it is. Please. I have no interest. I have done tons of therapy as have our kids. Nothing is directly wrong with me. I had my one big life altering love and Im okay with going the rest of my life reminiscing that.

My family has over the years tried to set me up, give me speeches and otherwise convince me to find a new romantic partner. I have tried everything to shut it down but they are adamant I need to date again, because of their constant pressure Ive distanced myself a lot. I still see them mostly for the kids sake. Im also very close to my in-laws and my husbands entire family.

My parents hosted a birthday dinner for my mom and during dinner Jane once again asked when I was gonna start dating and listed friends of her new husband who she thought suitable. I told her no and to please drop it, to which Jane replied with its been over six years, you need to get over it and move on. At this I kind of snapped, stood up and fi...

AI tokens surge, Binance launches NFT loans and one of crypto's biggest haters makes a surprising move. These stories and more, this week in crypto. AI Tokens Jump Following Nvidia Report AI-themed cryptocurrencies got a lift as Nvidia reported increasing demand for chips that power artificial inte

The Ethereum price has shown attempts at recovery during recent trading sessions. Over the past 24 hours, the price of this altcoin has experienced a modest increase of nearly 2%. However, when observing the weekly chart, the price has only managed to appreciate by 3%.

In terms of technical analysis, the outlook has favored the bulls, with buying strength exhibiting an uptick. Additionally, both demand and accumulation have displayed positive changes. As the price began to rise, ETH successfully surpassed a significant resistance level, crossing the $1,790 mark.

This breakthrough has enabled the bulls to gain control of the price action. Nevertheless, an important hurdle still remains to be overcome for ETH to witness a substantial rally. Notably, with the Bitcoin price demonstrating uncertain price action, several major altcoins have struggled to surpass their key price resistance levels.

As BTC surpassed $27,000, the broader markets increased strength might also contribute to the Ethereum upward price movement on its chart. The market capitalization of Ethereum witnessed an increase in the last trading session, indicating a return of buyers to the market.

Ethereum Price Analysis: One-Day Chart

At the time of writing, ETH was priced at $1,840. The altcoin has exhibited gradual appreciation following its breakthrough of the $1,790 resistance level.

However, ETH has experienced intermittent corrections, and in order to halt this pattern, it needs to surpass the overhead price ceiling of $1,870.

Surmounting this level would pave the way for ETH to trade near $1,900. Conversely, a drop from this level would bring ETH to $1,790 and subsequently to $1,740. The volume of ETH traded in the last session appeared positive, indicating reduced selling pressure on the chart.

Technical Analysis

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WENDELL HUSSEY | Cadet | CONTACT NSW Blues Coach Brad Fittler has today taken things outside the box in preparation for the State of Origin series opener. With the first game just over 48 hours away, the man in charge of the underperforming Blues has decided to mix things up. Ahead of a captains run tomorrow that will feature []

The post Skivvy Clad Brad Fittler Takes NSW Origin Team For Bonding Session At Barossa Valley Winery appeared first on The Betoota Advocate.

BAND prices remain stable at the time of writing. However, considering recent development within the Band Protocol ecosystem, there could be more upsides as the project unveils new features and strikes strategic partnerships.

Horizen Partnership

Recently, Band Protocol, a platform focusing on cross-chain data oracles, partnered with Horizen, a public blockchain offering a scalable ecosystem for decentralized applications (dapps). 

The goal is to provide EON, Horizens recently launched EVM-compatible intelligent contracting platform, with access to decentralized oracle services. In this way, decentralized finance (DeFi), gaming, and non-fungible tokens (NFTs) within the EON ecosystem will have real-time pricing information and reliable data via Band Protocols middleware solutions.

EON uses Band Protocols primary Oracle solution to provide real-time token price feeds across several blockchain networks. Integrating these two platforms ensures the integrity of EONs data, which will be essential in developing the companys DeFi, gaming, and NFT ecosystem.

Band Protocols ability to gather and integrate real-world data and APIs to intelligent contracts may help EON become less reliant on centralized oracles, which introduce points of failure. This new link allows programmers to enhance and expand the functionality of EON intelligent contracts.

According to Rob Viglione, co-founder, and CEO of Horizon Labs, the relationship with Band Protocol is a broad step forward in the companys efforts to provide a safe and scalable environment for DApps. 

The reliable oracle services provided by Band Protocol allow programmers to design innovative software for DeFi, gaming, and NFTs.

Integrating Band Protocols oracle solution, Horizen EON can now provide their intelligent contracts with accurate, real-time price data. Due to this collaboration, new possibilities in DeFi, gaming, and NFT applications will emerge, and the whole blockchain ecosystem will become more robust and decentralized.

Band Protocol Planning For SubDAOs

Moreover, Band Protocol has proposed the implementation of SubDAOs. 

According to Shine Sutheeravet, head of operations at Band Protocol, the goal is to address challenges in decentralized autonomous organizations (DAOs). 

SubDAOs offer solutions for complexity management, efficient resource allocation, specialized expertise, flexibility, inclusivity, and scalability. 

The proposal suggests transforming the Cosmos Group module into councils to establish clear governance structures. 

At the...

Ethereum, the worlds second-largest cryptocurrency by market capitalization, has witnessed a significant surge in its mean block size, reaching a new 1-month high. This milestone was recently announced by Glassnode, a renowned on-chain analysis platform.

The increase in block size indicates a notable improvement in Ethereums network capacity and transaction throughput, potentially bringing positive implications for the ecosystem.

Breaking Down The Block Size Surge

The mean block size of Ethereum has skyrocketed, surpassing the previous 1-month high recorded on May 27, 2023. Glassnodes data reveals that the current mean block size stands at 121.4 million.

This surge highlights a substantial increase in the average data volume accommodated within individual blocks of the Ethereum blockchain.

Larger block size is indicative of Ethereums ability to handle more data and transactions per block, effectively enhancing the networks capacity. With a higher average data volume in recent blocks, ETH showcases its potential for improved scalability and transaction throughput.

Ethereums surge in block size signifies a positive development for the ETH ecosystem, as it accommodates the growing demands and usage of the network.

What This Means For Ethereum

The surge in Ethereums mean block size holds several implications for ETH and its community. Firstly, it signifies the networks continued growth and adoption. As more participants engage with the Ethereum blockchain, the increased block size demonstrates the platforms ability t...

24-Hour Sale at My Modern Met Store: Save 15% On All of Our Creative Products

Memorial Day is the unofficial start to summer, and the warm weather and beach trips are reasons to jump for joy. We're marking this momentous time of year with a Memorial Day sale at My Modern Met Store. But act fastthis flash sale will only one day! On May 29and May 29 onlyuse the code HELLOSUMMER23 to save 15% on everything in our shop. This includes items already on sale.

Summer is the perfect time to gather with friends, and it's always a good idea to be prepared for a long catch-up session. For this special occasion, why not enjoy some fancy cocktails? The Bartender Glasses set includes four chic tumblers that feature four different recipes on the sides (for a total of 16 cocktails). With them, you'll be able to enjoy a crisp mojito or imbibe a Bloody Mary with brunch.

Another great summer tradition is visiting the farmers market. Youll need a chic bag for the occasion, of course! For that, look to LOQI. The company produces eco-friendly tote bags that feature masterpieces you can carry on your arm, such as Vincent van Goghs iconic painting Almond Blossom. The pretty turquoise tote has an all-over print showcasing the 19th-century painting to display the work in an exciting and contemporary way.

Visit My Modern Met Store to see our entire selection of creative products. When youre ready to check o...

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EFFIE BATEMAN | Lifestyle | Contact A local woman has this week been informed that her pronunciation of the word, FIFO, makes her sound like a hungry giant on a quest to feast on the bones of a young child, its reported. Its alleged Dana Hughes [25] had spotted the terms a few times on dating apps (which if []

The post Local Woman Urged To Stop Pronouncing FIFO Like Shes A Hungry Giant appeared first on The Betoota Advocate.

For some reason, the loss of a pet is often dismissed as a cause of trauma, and anybody who has ever experienced the tsunami of sadness that it can bring will know exactly what Im talking about.

A recent study aims to alter that by supplying counselors with fresh points of view that they should bear in mind while dealing with clients whose animals passed away.

When relationships are not valued by society, individuals are more likely to experience disenfranchised grief after a loss that cannot be resolved and may become complicated grief, stated Association for Pet Loss and Bereavement President and pet loss grief expert Colleen Rolland.

The major goals of this review are to provide counselors with an aspect to consider in their therapeutic work with clients dealing with grief and loss and present different factors that may impact how one grieves the loss of a pet. It also discusses considerations for counseling that can be utilized to foster a supportive and non-judgmental space where clients expressions of grief are validated.

There was an increase in both pet ownership and the amount of time individuals were spending with their pets towards the beginning of the COVID-19 pandemic, when lockdowns saw a third of humanity confined to their homes.

Studies have shown that having a pet may greatly improve a persons quality of life, even saving their lives during times of extreme loneliness. The prevalence of pet cemeteries across the world attests to the significance of pets to people.

Rolland and study co-author Dr. Michelle Crossley, Assistant Professor at Rhode Island College, think that mourning the death of a pet still isnt seen as a huge concern by many people despite the abundance of data demonstrating their worth.

They believe that if individuals worry that their sadness over a pets death would be received with ridicule, they may be less inclined to seek treatment when they actually need it, which might be harmful to their health.

Group therapy sessions (in-person or online) and therapeutic arts and crafts (especially for young children) are two methods suggested for helping clients cope with the death of a pet.

The goal of this study was to persuade therapists that the loss of a pet is significant for certain clients, and that validating grieving over animals is an important step toward facilitating recovery and expanding access to care.

When an individual loses a pet, it can be a traumatic experience, especially given the strength of attachment, the role the pet played in the life of the individual, as well as the circumstances and type of loss, said Crossley.

Giving a voice to individuals grieving a disenfranchised loss is one way in which counselors can help clients th...

Plans for a First Nations Voice to Parliament have been abandoned, with Indigenous leaders saying it will be easier to have a say on Government policy via a rolling contract with consulting firm PwC instead.

Announcing the new direction, members of the Yes campaign said putting PwC on retainer will save months of campaigning and lead to a better result.

Itll give us unfettered access to Government policy much more than The Voice ever would have. And we dont need to muck around with a Referendum; well just draw up a contract. Itll all be sorted by the end of the week. I wish wed thought of it earlier to be honest, an Indigenous spokesperson said.

He responded to fears the system would create a two-tiered society that would see some Australians granted more rights than others. Will it give us access to privileges that ordinary Australians dont enjoy? Fuck yes! Thats the way this thing works! Well be able to shape policy to our advantage, get access to confidential information, meet with Ministers, the whole lot. This is nothing like The Voice, its proper, unconstrained access.

The post Voice to Parliament Scrapped After Indigenous Leaders Realise Hiring PwC Will Give Better Access to Government appeared first on The Shovel.

PMID:  Viruses. 2022 May 17 ;14(5). Epub 2022 May 17. PMID: 35632821 Abstract Title:  Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor. Abstract:  Lipids play a crucial role in the entry and egress of viruses, regardless of whether they are naked or enveloped. Recent evidence shows that lipid involvement in viral infection goes much further. During replication, many viruses rearrange internal lipid membranes to create niches where they replicate and assemble. Because of the close connection between lipids and inflammation, the derangement of lipid metabolism also results in the production of inflammatory stimuli. Due to its pivotal function in the viral life cycle, lipid metabolism has become an area of intense research to understand how viruses seize lipids and to design antiviral drugs targeting lipid pathways. Palmitoylethanolamide (PEA) is a lipid-derived peroxisome proliferator-activated receptor-(PPAR-) agonist that also counteracts SARS-CoV-2 entry and its replication. Our work highlights for the first time the antiviral potency of PEA against SARS-CoV-2, exerting its activity by two different mechanisms. First, its binding to the SARS-CoV-2 S protein causes a drop in viral infection of ~70%. We show that this activity is specific for SARS-CoV-2, as it does not prevent infection by VSV or HSV-2, other enveloped viruses that use different glycoproteins and entry receptors to mediate their entry. Second, we show that in infected Huh-7 cells, treatment with PEA dismantles lipid droplets, preventing the usage of these vesicular bodies by SARS-CoV-2 as a source of energy and protection against innate cellular defenses. This is not surprising since PEA activates PPAR-, a transcription factor that, once activated, generates a cascade of events that leads to the disruption of fatty acid droplets, thereby bringing about lipid droplet degradation through-oxidation. In conclusion, the present work demonstrates a novel mechanism of action for PEA as a direct and indirect antiviral agent against SARS-CoV-2. This evidence reinforces the notion that treatment with this compound might significantly impact the course of COVID-19. Indeed, considering that the protective effects of PEA in COVID-19 are the current objectives of two clinical trials (NCT04619706 and NCT04568876) and given the relative lack of toxicity of PEA in humans, further preclinical and clinical tests will be needed to fully consider PEA as a promising adjuvant therapy in the current COVID-19 pandemic or against emerging RNA viruses that share the same route of replication as coronaviruses.

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Now that MTV News has shuttered, we are the only reputable source available that can quell your taste for new music. Its not the responsibility we asked for, nor the responsibility for which we have any formal training. Still, it is our burden to bear, goddamnit, and bear the shit out of it we will. Since we have to do everything for you now, weve compiled a list of some recent jams you may have been missing lately. Treat this as your free gateway to feeling relevant again and keep your eyes peeled for a sudden uptick of Kurt Loder written guest columns in the near future.

Blur The Narcissist

Everyone wants Oasis to get back together so badly (for some reason) that even Blur seem to be openly taunting the band by letting out some more of their perfect Brit-Pop. The Narcissist, is Blurs first new single in eight years and its absolutely gorgeous. If the ornate orchestration and production on this first teaser are any indication, were looking toward another opus from lead singer and songwriter Damon Albarn. With any luck, it will piss Noel and Liam off enough to get off their asses and make something that ultimately pales in comparison, but well likely have to settle for more childish tweets about it instead.

OSEES Intercepted Message

John Dwyer of OSEES (or however theyre spelling it this week) just announced what we are estimating is their thousandth album, Intercepted Message, last week. In a statement regarding the release of the title track, Dwyer promised a poppier side of the band on the forthcoming record. Of course, by his definition, poppier equates to a sound reminiscent of the Cars dropping an entire sheet of acid and performing a live concert in the depths of hell. All of this is to say, the song is very fucking good and you should stop whatever youre doing and put it on this instant.

Daft Punk Infinity Repeating (2013 Demo) [ft. Julian Casablanca and the Voidz]

Whether or not you choose to believe it, Daft Punks blockbuster album Random Access Memories came out 10 years ago. To celebrate, the robotic duo released an expanded refer to as demos. One major highlight is this incredibly catchy, amazingly produced and unreleased song featuring none other than Julian Casablanca and the Voidz...

PMID:  Biomolecules. 2022 May 5 ;12(5). Epub 2022 May 5. PMID: 35625595 Abstract Title:  Effects of Palmitoylethanolamide on Neurodegenerative Diseases: A Review from Rodents to Humans. Abstract:  Palmitoylethanolamide (PEA) stands out among endogenous lipid mediators for its neuroprotective, anti-inflammatory, and analgesic functions. PEA belonging to the N-acetylanolamine class of phospholipids was first isolated from soy lecithin, egg yolk, and peanut flour. It is currently used for the treatment of different types of neuropathic pain, such as fibromyalgia, osteoarthritis, carpal tunnel syndrome, and many other conditions. The properties of PEA, especially of its micronized or ultra-micronized forms maximizing bioavailability and efficacy, have sparked a series of innovative research to evaluate its possible application as therapeutic agent for neurodegenerative diseases. Neurodegenerative diseases are widespread throughout the world, and although they are numerous and different, they share common patterns of conditions that result from progressive damage to the brain areas involved in mobility, muscle coordination and strength, mood, and cognition. The present review is aimed at illustrating in vitro and in vivo research, as well as human studies, using PEA treatment, alone or in combination with other compounds, in the presence of neurodegeneration. Namely, attention has been paid to the effects of PEA in counteracting neuroinflammatory conditions and in slowing down the progression of diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Frontotemporal dementia, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis. Literature research demonstrated the efficacy of PEA in addressing the damage typical of major neurodegenerative diseases.

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PMID:  Clin Neurol Neurosurg. 2022 Jul ;218:107282. Epub 2022 May 8. PMID: 35598579 Abstract Title:  Palmitoylethanolamide-based nutraceutical Calmuxin preventive treatment of migraine. Abstract:  BACKGROUND: The aim of this study was to determine the efficacy and tolerability of treatment with a Palmitoylethanolamide (PEA)-based nutraceutical in patients with episodic migraine.METHODS: A pilot, prospective, open-label experimental study was designed in which patients with episodic migraine with and without aura seen in the general practice office of a tertiary centre during a period of 6 month were offered the possibility to participate. No control group was included. All included patients were treated with nutraceutical Calmuxtaken every 12 h for 3 months. Monthly attack frequency, attack intensity, impact of migraine (HIT-6 and MIDAS scales) and quality of sleep at baseline and after 3 months of treatment were compared.RESULTS: Twenty-five patients (22 women and 3 men) were included, with a mean age of 36.3  12 years. Headache days per month decreased from 10  2.1 days to 6.6  3.6 days (p 

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While no misconduct was determined by Temaseks internal review, staff involved with the FTX investment will see a dent in their pay package.

Indian politicians and policy makers at a crypto event by CoinDCX and Bharat Web3

PMID:  Neurosci Lett. 2022 Jun 11 ;781:136648. Epub 2022 Apr 22. PMID: 35469820 Abstract Title:  Palmitoylethanolamide ameliorates neuroinflammation via modulating PPAR-to promote the functional outcome after intracerebral hemorrhage. Abstract:  Intracerebral hemorrhage is a type of acute cerebrovascular disease that remains one of the main causes of death and disability. After the onset of ICH, different types of severe pathophysiological changes can cause great damage to brain tissue, including neuroinflammation. Our study demonstrated the effect of PEA on modulating microglia phenotype and neuroinflammation, as well as the possible underlying mechanisms after ICH for the first time. The phenotypic transformation of microglia and simulation of neuroinflammation after ICH in vitro was induced by hemoglobin on BV2 cells. Additionally, the experiment in vivo model was induced by collagenase injection in mice. The role of PEA on hematoma clearance was also discussed. Western blot, ELISA and immunofluorescence staining were used to determine the phenotypic polarization of microglia and neuroinflammation. In order to evaluate the role of PPAR-in the anti-inflammatory effect of PEA after ICH, the PPAR-antagonist GW6471 was utilized. Behavior tests examined the effect of PEA on improving neuronal function. Our results showed that PEA can ameliorate neuroinflammation by inhibiting upregulation of NF-B, IL-1and TNF-, both in vivo and in vitro. Additionally, PEA can improve motor function in ICH mice and promotes hematoma clearance. At the same time, PEA can increase the levels of PPAR-in the nucleus. Hence, PPAR-antagonists can reverse the protective effects of PEA on neuroinflammation. These results suggest that PEA is involved in microglia polarization, attenuating the activation of neuroinflammation, as well as improving motor function after ICH. This, at least in part, may contribute to the involvement of PPAR-modulation of NF-B.

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PMID:  Innov Clin Neurosci. 2022 ;19(1-3):19-25. PMID: 35382075 Abstract Title:  Could Palmitoylethanolamide Be an Effective Treatment for Long-COVID-19? Hypothesis and Insights in Potential Mechanisms of Action and Clinical Applications. Abstract:  COVID-19 is highly transmissive and contagious disease with a wide spectrum of clinicopathological issues, including respiratory, vasculo-coagulative, and immune disorders. In some cases of COVID-19, patients can be characterized by clinical sequelae with mild-to-moderate symptoms that persist long after the resolution of the acute infection, known as long-COVID, potentially affecting their quality of life. The main symptoms of long-COVID include persistent dyspnea, fatigue and weakness (that are typically out of proportion, to the degree of ongoing lung damage and gas exchange impairment), persistence of anosmia and dysgeusia, neuropsychiatric symptoms, and cognitive dysfunctions (such as brain fog or memory lapses). The appropriate management and prevention of potential long-COVID sequelae is still lacking. It is also believed that long-term symptoms of COVID-19 are related to an immunity over-response, namely a cytokine storm, involving the release of pro-inflammatory interleukins, monocyte chemoattractant proteins, and tissue necrosis factors. Palmitoylethanolamide (PEA) shows affinity for vanilloid receptor 1 and for cannabinoid-like G protein-coupled receptors, enhancing anandamide activity by means of an entourage effect. Due to its anti-inflammatory properties, PEA has been recently used as an early add-on therapy for respiratory problems in patients with COVID-19. It is believed that PEA mitigates the cytokine storm modulating cell-mediated immunity, as well as counteracts pain and oxidative stress. In this article, we theorize that PEA could be a potentially effective nutraceutical to treat long-COVID, with regard to fatigue and myalgia, where a mythocondrial dysfunction is hypothesizable.

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PMID:  Pharmaceuticals (Basel). 2022 Feb 19 ;15(2). Epub 2022 Feb 19. PMID: 35215365 Abstract Title:  Effects of Ultramicronized Palmitoylethanolamide (um-PEA) in COVID-19 Early Stages: A Case-Control Study. Abstract:  Ultramicronized palmitoylethanolamide (um-PEA), a compound with antioxidant, anti-inflammatory and neuroprotective properties, appears to be a potential adjuvant treatment for early stages of Coronavirus disease 2019 (COVID-19). In our study, we enrolled 90 patients with confirmed diagnosis of COVID-19 that were randomized into two groups, homogeneous for age, gender and BMI. The first group received oral supplementation based on um-PEA at a dose of 1800 mg/day for a total of 28 days; the second group was the control group (R.S. 73.20). At baseline (T0) and after 28 days of um-PEA treatment (T1), we monitored: routine laboratory parameters, inflammatory and oxidative stress (OS) biomarkers, lymphocytes subpopulation and COVID-19 serological response. At T1, the um-PEA-treated group presented a significant reduction in inflammation compared to the control group (CRP= 0.007; IL-6= 0.0001; neutrophils to lymphocytes ratio= 0.044). At T1, the controls showed a significant increase in OS compared to the treated group (FORT= 0.05). At T1, the um-PEA group exhibited a significant decrease in D-dimer levels (= 0.0001) and higher levels of IgG against SARS-CoV-2 (= 0.0001) compared to the controls. Our data demonstrated, in a randomized clinical trial, the beneficial effects of um-PEA in both asymptomatic and mild-symptomatic patients related to reductions in inflammatory state, OS and coagulative cascade alterations.

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PMID:  Int J Mol Sci. 2021 Oct 21 ;22(21). Epub 2021 Oct 21. PMID: 34768820 Abstract Title:  Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation. Abstract:  Disseminated intravascular coagulation (DIC) is a severe condition characterized by the systemic formation of microthrombi complicated with bleeding tendency and organ dysfunction. In the last years, it represents one of the most frequent consequences of coronavirus disease 2019 (COVID-19). The pathogenesis of DIC is complex, with cross-talk between the coagulant and inflammatory pathways. The objective of this study is to investigate the anti-inflammatory action of ultramicronized palmitoylethanolamide (um-PEA) in a lipopolysaccharide (LPS)-induced DIC model in rats. Experimental DIC was induced by continual infusion of LPS (30 mg/kg) for 4 h through the tail vein. Um-PEA (30 mg/kg) was given orally 30 min before and 1 h after the start of intravenous infusion of LPS. Results showed that um-PEA reduced alteration of coagulation markers, as well as proinflammatory cytokine release in plasma and lung samples, induced by LPS infusion. Furthermore, um-PEA also has the effect of preventing the formation of fibrin deposition and lung damage. Moreover, um-PEA was able to reduce the number of mast cells (MCs) and the release of its serine proteases, which are also necessary for SARS-CoV-2 infection. These results suggest that um-PEA could be considered as a potential therapeutic approach in the management of DIC and in clinical implications associated to coagulopathy and lung dysfunction, such as COVID-19.

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PMID:  Biochem Biophys Res Commun. 2021 Aug 20 ;566:164-169. Epub 2021 Jun 11. PMID: 34126347 Abstract Title:  PEA prevented early BBB disruption after cerebral ischaemic/reperfusion (I/R) injury through regulation of ROCK/MLC signaling. Abstract:  Palmitoylethanolamide (PEA) offers a strong protection against BBB disruption and neurological deficits after cerebral ischaemic/reperfusion (I/R) injury. To date, these BBB protective effects of PEA are mainly attributed to PPAR-mediated actions. However, whether PEA protects against BBB disruption through direct regulation of cytoskeletal microfilaments remains unknown. Here, we identified PEA as a Rho-associated protein kinase (ROCK2) inhibitor (IC = 38.4  4.8 M). In vitro data suggested that PEA reduced the activation of ROCK/MLC signaling and stress fiber formation within microvascular endothelial cells (ECs) after oxygen-glucose deprivation (OGD), and consequently attenuated early (0-4 h) EC barrier disruption. These actions of PEA could not be blocked by the PPARantagonist GW6471. In summary, the present study described a previously unexplored role of PEA as a ROCK2 inhibitor, and propose a PPAR-independent mechanism for pharmacological effects of PEA.

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PMID:  Antioxidants (Basel). 2021 Mar 16 ;10(3). Epub 2021 Mar 16. PMID: 33809584 Abstract Title:  PEA/Polydatin: Anti-Inflammatory and Antioxidant Approach to Counteract DNBS-Induced Colitis. Abstract:  Palmitoylethanolamide (PEA) has well-known anti-inflammatory effects. However, PEA does not possess an antioxidant ability. A comicronized formulation of ultramicronized PEA (um-PEA) and polydatin (Pol) PEA/Pol, a biological precursor of resveratrol with antioxidant activity, could have protective effects on oxidative stress produced by inflammatory processes. We evaluated the effects of a comicronized PEA/Pol 10 mg/kg (9 mg of um-PEA+1 mg of polydatin) in a model of Dinitrobenzene sulfonic acid (DNBS)-induced colitis. Ulcerative colitis was induced in mice by intrarectally injection of DNBS (4 mg in 100L of 50% ethanol per mouse). Macroscopic and histologic colon alterations and marked clinical signs were observed four days after DNBS and elevated cytokine production. The myeloperoxidase (MPO) activity assessed for neutrophil infiltration was associated with ICAM-1 and P-selectin adhesion controls in colons. Oxidative stress was detected with increased poly ADP-ribose polymerase (PARP) and nitrotyrosine positive staining and malondialdehyde (MDA) levels in inflamed colons. Macroscopic and histologic alterations minimized by oral PEA/Pol, as well as neutrophil infiltration, inflammatory cytokine release, MDA, nitrotyrosine, PARP and ICAM-1, and P-selectin expressions. The mechanism of action of PEA/Pol could be related to the sirtuin 1/nuclear factor erythroid 2-related factor 2 (SIRT-1/Nrf2) pathway and nuclear factor (NF)-B. PEA/Pol administration inhibited NF-B and increased SIRT-1/Nrf2 expressions. Our results show that PEA/Pol is capable of decreasing inflammatory bowel disease (IBD) DNBS-induced in mice.

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Its owner acquired the tokens during Ethereums ICO in 2015, when each ETH was worth only 31 cents each.

PMID:  Medicina (Kaunas). 2023 Jan 18 ;59(2). Epub 2023 Jan 18. PMID: 36837393 Abstract Title:  Hemp Seed Oil in Association with-Caryophyllene, Myrcene and Ginger Extract as a Nutraceutical Integration in Knee Osteoarthritis: A Double-Blind Prospective Case-Control Study. Abstract:  Nutraceuticals are gaining more and more importance as a knee osteoarthritis (KOA) complementary treatment. Among nutraceuticals, hemp seed oil and terpenes are proving to be very useful as therapeutic support for many chronic diseases, but there are still few studies regarding their effectiveness for treating KOA, both in combination and separately. The aim of this study is thus to compare the effect of two dietary supplements, both containing hemp seed oil, but of which only one also contains terpenes, in relieving pain and improving joint function in patients suffering from KOA.Thirty-eight patients were recruited and divided into two groups. The control group underwent a 45 day treatment with a hemp seed oil-based dietary supplement, while the treatment group assumed a hemp seed oil and terpenes dietary supplement for the same period. Patients were evaluated at the enrollment (T0) and at the end of treatment (T1). Outcome measures were: Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), Short-Form-12 (SF-12), Knee Injury Osteoarthritis Outcome Score (KOOS), and Oxford Knee Score (OKS).All outcome measures improved at T1 in both groups, but NRS, KOOS and OKS had a greater significant improvement in the treatment group only.Hemp seed oil and terpenes resulted a more effective integrative treatment option in KOA, improving joint pain and function and representing a good complementary option for patients suffering from osteoarthritis.

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PMID:  Int J Mol Sci. 2021 Feb 17 ;22(4). Epub 2021 Feb 17. PMID: 33671213 Abstract Title:  Effect of Ultra-Micronized-Palmitoylethanolamide and Acetyl-l-Carnitine on Experimental Model of Inflammatory Pain. Abstract:  Palmitoylethanolamide (PEA), a fatty acid amide, has been widely investigated for its analgesic and anti-inflammatory properties. The ultra-micronized formulation of PEA (um-PEA), that has an enhanced rate of dissolution, is extensively used. Acetyl-l-carnitine (LAC), employed for the treatment of neuropathic pain in humans, is able to cause analgesia by up-regulating type-2 metabotropic glutamate (mGlu2) receptors. In the present study, we tested different associations of um-PEA, LAC and non-micronized PEA (non-m-PEA) in a rat model of carrageenan (CAR)-induced paw edema. Intraplantar injection of CAR into the hind paw of animals caused edema, thermal hyperalgesia, accumulation of infiltrating inflammatory cells and augmented myeloperoxidase (MPO) activity. All these parameters were decreased in a significantly manner by oral administration of a compound constituted by a mixture of um-PEA and LAC in relation 1:1 (5 mg/kg), but not with the association of single compounds administered one after the other. These findings showed the superior anti-inflammatory and anti-nociceptive action displayed by oral administration of um-PEA and LAC versus LAC plus, separate but consecutive, um-PEA in the rat paw CAR model of inflammatory pain.

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CLANCY OVERELL | Editor | CONTACT Melbourne residents are absolutely stoked to hear that they are still at risk of aftershocks, after the city was struck by its strongest earthquake in 120 years overnight. More than a year since the limelight faded on Melbourne residents after they were finally released from their state-sanctioned-quarantine, the city is thrilled to be []

The post Melbourne Resident Says 3.8 Magnitude Earthquake Not Really As Bad As The Extra Long Lockdown They Had To Endure To Protect The Rest Of The Country Even Though No One Ever Said Thank You Or Whatever appeared first on The Betoota Advocate.

(Pixabay)

I was always pretty lucky with decent landlords when I rented apartments in my younger daysexcept for one company.

They were known as slumlords in the town I lived in for a few years and they definitely lived up to their reputation.

And it seems like there are a lot of landlords and property management companies these days that will do anything to make an extra buckincluding taking as much of a persons security deposit as they can.

A woman shared a video on TikTok where she put her old landlords on blast after they only gave her back a fraction of her security deposit despite the fact that she left the place clean and in good shape

...

WENDELL HUSSEY | Cadet | CONTACT Popular morning television host David Koch has today confirmed that he will be standing down as the host of Sunrise. The long time host of the Channel 7 program made the announcement live on air this morning, shocking viewers of the program who apparently thought he would go on hosting the show for []

The post David Koch Retires To Spend More Time On His Internet Crypto Currency Scams appeared first on The Betoota Advocate.

Heres what the Democratic and Republican candidates running for the job of president of the United States have said about crypto.

ERROL PARKER | Editor-at-large | Contact A French Quarter barfly remarked to our reporter this morning that he finds it nice to see kids putting their phones, tablets and PlayStations down for a change and deriving some fun from the great outdoors. When asked what he meant by that, 79-year-old day drinker Max Near-Ross said []

The post You Know, Its Nice To See Kids Having Fun Outside For Once Says Local Old Codger appeared first on The Betoota Advocate.

Something really remarkable has been accomplished by a group of engineers. A device that continually extracts energy from moist air may be crafted out of almost any substance, since there is no one optimal choice.

It is a development that is not yet ready for practical implementation, but its developers claim that it transcends some of the constraints that other harvesters have. All that is required of the material is to be pocked with nanopores with a diameter of less than 100 nanometers.

Thats about one-thousandth the breadth of a human hair, so its easier to say than it is to accomplish, but its really far simpler than anybody anticipated.

A group of researchers at the University of Massachusetts Amherst, headed by engineer Xiaomeng Liu, found that this kind of material has the ability to capture the energy created by small water droplets in humid air.

They have coined the phrase generic Air-gen effect to refer to their finding.

Artists impression of an Air-gen device. (Derek Lovley/Ella Maru Studio)

The air contains an enormous amount of electricity, says engineer Jun Yao of UMass Amherst. Think of a cloud, which is nothing more than a mass of water droplets. Each of those droplets contains a charge, and when conditions are right, the cloud can produce a lightning bolt but we dont know how to reliably capture electricity from lightning. What weve done is to create a human-built, small-scale cloud that produces electricity for us predictably and continuously so that we can harvest it.

If the name Air-gen rings a bell, it is because the team has worked on the creation of an air energy harvester in the past. However, an earlier version of their technology was dependent on protein nanowires that were produced by a bacteria known as Geobacter sulfurreducens.

It has come to light that the bacteria in question used in the past is not essential to the process.

What we realized after making the Geobacter discovery is that the ability to generate electricity from the air what we then called the Air-gen effect turns out to be generic: literally any kind of material can harvest electricity from air, as long as it has a certain property, ...

PMID:  Int J Biol Macromol. 2023 Apr 15 ;234:123171. Epub 2023 Jan 27. PMID: 36716837 Abstract Title:  Bacopa monnieri reduces Tau aggregation and Tau-mediated toxicity in cells. Abstract:  Alzheimer's disease is a neurodegenerative disease characterized by progressive memory loss and behavioral impairments. In the present study, the ethanolic extract of Bacopa monnieri was studied for its potency to inhibit Tau aggregation and rescuing of the viability of Tau-stressed cells. Bacopa monnieri was observed to inhibit the Tau aggregation in vitro. The cells exposed to Bacopa monnieri were also observed to have a low level of ROS and caspase-3 activity. The immunoblot and immunofluorescence analysis showed that Bacopa monnieri acts as an antioxidant and restored the Nrf2 levels in Neuro2a cells. Bacopa monnieri treatment to Neuro2a cells was observed to reduce the phospho-Tau load in formaldehyde-stressed cells. Furthermore, the treatment of Bacopa monnieri reduced the phosphorylation of GSK-3in formaldehyde-stressed cells. Ran and NUP358 are the key proteins involved in nuclear transport. It was observed that formaldehyde treatment impaired the nuclear transport by missorting the NUP358 arrangement in Neuro2a cells. On the contrary, Bacopa monnieri treatment restored the NUP358 arrangement in cells. The overall results of the present study suggested that Bacopa monnieri could be considered a potent herb against Tau phosphorylation and Tau aggregation, which projects it as a promising formulation for Alzheimer's disease.

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PMID:  Int J Mol Sci. 2023 Mar 6 ;24(5). Epub 2023 Mar 6. PMID: 36902479 Abstract Title:  Cannabidiol as a Promising Therapeutic Option in IC/BPS: In Vitro Evaluation of Its Protective Effects against Inflammation and Oxidative Stress. Abstract:  Several animal studies have described the potential effect of cannabidiol (CBD) in alleviating the symptoms of interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic inflammatory disease of the urinary bladder. However, the effects of CBD, its mechanism of action, and modulation of downstream signaling pathways in urothelial cells, the main effector cells in IC/BPS, have not been fully elucidated yet. Here, we investigated the effect of CBD against inflammation and oxidative stress in an in vitro model of IC/BPS comprised of TNF-stimulated human urothelial cells SV-HUC1. Our results show that CBD treatment of urothelial cells significantly decreased TNF-upregulated mRNA and protein expression of IL1, IL8, CXCL1, and CXCL10, as well as attenuated NFB phosphorylation. In addition, CBD treatment also diminished TNF-driven cellular reactive oxygen species generation (ROS), by increasing the expression of the redox-sensitive transcription factor Nrf2, the antioxidant enzymes superoxide dismutase 1 and 2, and hem oxygenase 1. CBD-mediated effects in urothelial cells may occur by the activation of the PPARreceptor since inhibition of PPARresulted in significantly diminished anti-inflammatory and antioxidant effects of CBD. Our observations provide new insights into the therapeutic potential of CBD through modulation of PPAR/Nrf2/NFB signaling pathways, which could be further exploited in the treatment of IC/BPS.

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PMID:  In Vivo. 2023 ;37(2):591-595. PMID: 36881078 Abstract Title:  Anti-inflammatory Effect of a Combination of Cannabidiol andExtract on Lipopolysaccharide-stimulated RAW264 Macrophages. Abstract:  BACKGROUND/AIM: The inflammatory response plays an important role in the activation and progression of many inflammation-related diseases. Cannabis sativa and Morinda citrifolia have long been used in folk medicine to treat inflammation. Cannabidiol is the most abundant non-psychoactive phytocannabinoid in C. sativa and exhibits anti-inflammatory activity. The objective of this study was to examine the anti-inflammatory effect of cannabidiol in combination with M. citrifolia and compare its effects with those of cannabidiol alone.MATERIALS AND METHODS: RAW264 cells stimulated with lipopolysaccharide (200 ng/ml) were treated with cannabidiol (0-10M), M. citrifolia seed extract (0-100g/ml), or a combination of both for 8 or 24 h. Following the treatments, nitric oxide production in the activated RAW264 cells and the expression of inducible nitric oxide synthase were assessed.RESULTS: Our results showed that combination of cannabidiol (2.5M) and M. citrifolia seed extract (100g/ml) exhibited more efficient inhibition of nitric oxide production than cannabidiol treatment alone in lipopolysaccharide-stimulated RAW264 cells. The combination treatment also reduced the expression of inducible nitric oxide synthase.CONCLUSION: These results suggest that the anti-inflammatory effect of combined treatment with cannabidiol and M. citrifolia seed extract causes a reduction in the expression of inflammatory mediators.

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The video above features a compilation of some of the most absurd COVID narratives we were indoctrinated with over the past three years. For example, No one is safe until everyone is safe was one of several lies we heard repeated across media platforms.

First of all, there were and are vast differences in risk depending on your age and general medical history, and this was evident within weeks of the outbreak. Secondly, the data showed that 99.5% of the population would survive COVID.

So, the reality was the complete opposite of this fabricated PR campaign slogan. Had we been told the truth, we would have been told that Most of us are safe, rather than None of us are safe.

One False PR Slogan After Another

Next, the no one is safe slogan morphed to No one is safe unless everyone is vaccinated. With that, it became open season to harass, intimidate, threaten and discriminate against the unvaccinated. Every COVID case and death was blamed on them, no matter how irrational. And while the talking heads paid lip service to the desire to save lives, they had no qualms about wishing death on the unvaccinated.

As questions about the safety of the experimental gene transfer shots mounted, another campaign slogan was concocted: Dont do your own research. At the same time, Trust the science was trending. What that meant was that you were supposed to trust that what you were told WAS the science. Actually looking at published science, that made you a dangerous moron.

One of the most egregious lies spread by mainstream media hosts and health authorities like Dr. Anthony Fauci alike was that the COVID vaccine would stop the spread of infection in its tracks, thereby ending the pandemic.

It was a provable lie, because anyone who had gone against the grain and done their own research knew that none of the COVID shots had ever been tested to see if they could prevent the spread of infection. The only promise they ever held was that they might reduce the symptoms of infection. Have any of these people apologized for spreading lies? I cant think of one.

Even Fauci and Walensky, then-director of the U.S. Centers for Disease Control and Prevention, stated that you could not get COVID if you got the shot. Both later got sick with COVID several times, as did countless others who fell for and vigorously promoted this false propaganda.

Still, the brainwashing continued. As hospitals filled up with vaccinated individuals who were supposed to be immune, the PR slogan Pandemic of the unvaccinated was endlessly circulated until the reality of the situation finally became t...

Common fennel (Foeniculum vulgare) is a perennial plant in the carrot family that is grown for the edible leaves, shoots, seeds and bulbs. It's likely the plant was first cultivated in Israel,¹ and is believed to have been part of Jewish meals since biblical times. The plant is native to the Mediterranean area, where the seeds are used as a spice, insect repellent and medicine, and the shoots and feathery fronds are added to salad.

Pliny the Elder mentions fennel several times in his encyclopedia, Natural History, as a treatment for uterine health, stomach aches, and to care for stings of serpents.² Although the plant has become an invasive species in parts of the U.S., it can be grown in pots, which may help contain the spread.³

The plant appreciates cool weather and temperatures above 75 degrees Fahrenheit can induce bolting, or premature seeding.⁴ It likes full sun, well-draining soil and should be planted in the early spring or fall months. If the seed heads are collected before they shatter, it may also help prevent the spread of the plant. Although the plant can reach 6 feet in height, it often is ready for harvest when it's shorter than that.⁵

Traditionally, the medicinal value of fennel has benefited nursing women and people with gastrointestinal disorders; it has even been used as a mild diuretic to help reduce edema. However, some people don't like the licorice-like flavor of the fennel plant, which tastes like anise.

Is It Anise or Fennel?

Although anise and fennel are similar in taste and the plants are from the same family, that is where the similarity ends. While fennel produces a bulb at the base that is edible, anise grows as a bush that produces the seed, and only the anise seed is edible.⁶

Both plants are native to the Mediterranean and both have a licorice flavor derived from anethole, an essential oil found in the seed. Many cooks use the seeds interchangeably, but anise is more pungent and often found in Chinese five spice powder. Fennel seeds have a less sweet licorice flavor that lends itself to savory dishes.

Fennel is a versatile plant and much of it can be eaten.⁷ The bulb can be trimmed, the outer layer peeled, and the bulb cut in half lengthwise through the middle of the root. The core can be tough on larger bulbs but is often tender in younger plants.

The fennel bulb and stocks c...

Editor's Note: This article is a reprint. It was originally published February 12, 2018.

The perennial plant rhodiola rosea, sometimes called "golden root," "roseroot" or "arctic root," is a powerful adaptogen known to enhance vitality by helping your body adapt to physical, chemical and environmental stress. In other words, it helps your body maintain homeostasis. The plant has a long history of use in traditional folk medicine in Russia and Scandinavian countries,¹ and modern science has shown rhodiola:^2,3,4,5,6

Has antidepressant and antianxiety benefits7 and helps improve symptoms of burnout	Enhances cognitive function, improving mental clarity, thought formation and focus
Helps modulate immune function (raising low immune function and reducing overactive function)	Enhances nervous system health
Enhances cardiovascular health	Improves male and female sexual functioning, reproductive health and fertility
Improves blood sugar control in diabetics when combined with cinnamon	Has anticancer benefits
Helps protect against viral infections8	Enhances athletic performance and shortens recovery time between workouts

Exercise Benefits of Rhodiola

A 2004 study⁹ found extract of rhodiola rosea radix had an anti-inflammatory effect on healthy untrained volunteers, before and after bouts of exhausting exercise. It also protected muscle tissue during exercise. According to the abstract:

"Professional athletes effectively use rhodiola rosea ('golden radix') extract as a safe n...

Staking rewards following Ethereums Shanghai upgrade have made it easier for investigators to spot counterintuitive behavior by ETH holders.

PMID:  J Neuroinflammation. 2023 Feb 10 ;20(1):31. Epub 2023 Feb 10. PMID: 36765376 Abstract Title:  Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy. Abstract:  OBJECTIVE: Patients with hypertension have a risk of depression. Morinda officinalis oligosaccharides (MOOs) have anti-depressant properties. In this study, we aimed to determine whether MOOs can improve the symptoms of depression in individuals with hypertension.METHODS: Dahl salt-sensitive rats fed with a high-salt diet were stimulated by chronic unpredictable mild stress to mimic hypertension with depression. Primary astrocytes and neurons were isolated from these rats. Astrocytes underwent LPS stimulation to simulate the inflammatory astrocytes during depression. MOOs were administrated at 0.1 mg/g/day in vivo and 1.25, 2.5, and 5 mg/mL in vitro. Mitophagy was inhibited using 5 mM 3-methyladenine (3-MA). Astrocyte-mediated neurotoxicity was detected by co-culturing astrocytes and neurons.RESULTS: MOOs decreased systolic pressure, diastolic pressure, and mean arterial pressure, thereby improving depression-like behavior, including behavioral despair, lack of enthusiasm, and loss of pleasure during hypertension with depression. Furthermore, MOOs inhibited inflammation, astrocytic dysfunction, and mitochondrial damage in the brain. Then, MOOs promoted autophagosome and lysosome enriched in mitochondria in LPS-stimulated astrocytes. MOOs suppressed mitochondrial damage and the release of tumor necrosis factor-(TNF-), interleukin (IL)-6, and IL-1in astrocytes undergoing LPS stimulation. Importantly, MOOs rescued the impaired neurons co-cultured with astrocytes. The effects of MOOs on LPS-stimulated astrocytes were reversed by 3-MA. Finally, MOOs upregulated LPS-downregulated Mfn2 expression in astrocytes. Mfn2 inhibition partly reversed the effects of MOOs on hypertension with depression. Intriguingly, Mfn2 suppression activated PI3K/Akt/mTOR pathway during MOOs treatment.CONCLUSIONS: Astrocytes develop neuroinflammation in response to mitochondrial damage during hypertension with depression. MOOs upregulated Mfn2 expression to activate the PI3K/Akt/mTOR pathway-mediated mitophagy, thereby removing impaired mitochondria in astrocytes.HIGHLIGHTS: 1. MOOs have anti-hypertensive and anti-depressive properties. 2. MOOs inhibit inflammation and injury in astrocytes during hypertension with depression. 3. MOOs induce mitophagy activation in inflammatory astrocytes with mitochondrial damage. 4. MOOs upregulate Mfn2 expression in astrocytes. 5. Mfn2 activates mitophagy to resist mitochondrial damage in astrocytes.

...

PMID:  Front Biosci (Landmark Ed). 2023 Feb 24 ;28(2):34. PMID: 36866542 Abstract Title:  The Investigation of the Molecular Mechanism ofHow in the Treatment of Heart Failure. Abstract:  Heart failure (HF) is a cardiovascular disease with an extremely high mortality rate. However,How (MO) has not been studied for cardiovascular purposes at this time, the aim of this study was to find new mechanism for the MO of treatment of HF through a bioinformatics and experimental validation. The present study also aimed to establish a link between the basic and clinical applications of this medicinal herb. MO compounds and targets were obtained by traditional Chinese medicine systems pharmacology (TCMSP) and Pubchem. Subsequently, HF targets were acquired from DisGeNET and the interactions of all the targets and other human proteins were obtained via String so as to establish a component-target interaction network by Cytoscape 3.7.2. All the targets of clusters were inserted into Database for Annotation, Visualization and Integrated Discovery (DAVID) to perform GO (gene ontology) enrichment analysis. Molecular docking was adopted to predict the targets of MO relevant to the treatment of HF and to further explore the associated pharmacological mechanisms. Subsequently, a series ofexperiments, including histopathological staining, immunohistochemical and immunofluorescence analyses were conducted for further verification. Moreover, western blot analysis andexperiments were performed. The results indicated that MO alleviated apoptosis, regulated cholesterol metabolism and transport function, and reduced inflammation, which resulted in the successful treatment of HF. Beta-sitosterol, Asperuloside tetraacetate and americanin A were the key bioactive components of MO. ALB, AKT1, INS, STAT3, IL-6, TNF, CCND1, CTNNB1, CAT, and TP53 were the core potential targets, which were significantly associated with multiple pathways, namely the FoxO signaling pathway, the AMPK signaling pathway, and the HIF-1 signaling pathway.experiments validated that MO may protect against heart failure or treat this disease by increasing the levels of autophagy via the FoxO3 signaling pathway in rats. The present study suggested that a combination of network pharmacology prediction with experimental validation may offer a useful tool to characterize the molecular mechanism of action of the traditional Chinese medicine (TCM) MO in the treatment of HF.

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PMID:  J Cosmet Dermatol. 2023 May ;22(5):1602-1612. Epub 2023 Jan 14. PMID: 36639978 Abstract Title:  Morinda officinalis extract exhibits protective effects against atopic dermatitis by regulating the MALAT1/miR-590-5p/CCR7 axis. Abstract:  BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a genetic predisposition, and the traditional Chinese medicine Morinda officinalis and its roots are characterized with anti-inflammatory effects and have been used for the treatment of various disease. However, it is still largely unknown whether Morinda officinalis extract (MOE) can be used for the treatment of AD.OBJECTIVES: In our study we aimed to determine whether MOE could ameliorate 2,4-dinitrochlorobenzene (DNCB)-induced AD and elucidate molecular mechanisms.METHODS: We established an AD mouse model by using DNCB. Skin pathological analysis and ELISA assay were used to detect the effect of MOE on the inflammation of AD model mouse skin and the expression changes of inflammatory factors, and further functional verification was performed in TNF-/IFN--induced HaCaT cells.RESULTS: Our in vivo experiments confirmed that MOE remarkably reduced DNCB-induced AD lesions and symptoms, such as epidermal and dermal thickness and mast cell infiltration and inflammatory cytokines secretion in the mice models. In addition, the underlying mechanisms by which MOE ameliorated AD had been uncovered, and we verified that MOE inhibited MALAT1 expression in AD, resulting in attenuated expression of C-C chemokine receptor type 7 (CCR7) regulated by MALAT1-sponge miR-590-5p in a competing endogenous RNA (ceRNA) mechanisms-dependent manner, thereby inhibiting TNF-/IFN--induced cellular proliferation and inflammation.

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PMID:  Fitoterapia. 2023 Jan ;164:105354. Epub 2022 Nov 17. PMID: 36403943 Abstract Title:  Methyl 2-naphthoates with anti-inflammatory activity from Morinda officinalis. Abstract:  Chemical fractionation of the EtOH extract of the roots of a traditional Chinese herb, Morinda officinalis, afforded an array of methyl 2-naphthoate derivatives (1-9) including four pairs of enantiomers (1-4), two pimarane diterpenes and two ursane triterpenoids. Among them, eight compounds (1a/1b-3a/3b, 11 and 13) were reported in the current work for the first time. The structures of the new compounds, including their absolute configurations, were defined by spectroscopic analyses in combination with quantum chemical electronic circular dichroism (ECD) and gauge-independent atomic orbital (GIAO) NMR calculations. All the isolates were evaluated for their inhibitory effect on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in murine RAW264.7 macrophage cells, and the enantiomers 1a and 3b exhibited moderate activity with ICvalues of 41.9 and 26.2 M. Meanwhile, compound 3b also dose-dependently inhibited the secretion of two pro-inflammatory cytokines TNF-and IL-6 in the same cell model.

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PMID:  Nutrients. 2023 Feb 4 ;15(4). Epub 2023 Feb 4. PMID: 36839161 Abstract Title:  The Inhibition of Autophagy and Pyroptosis by an Ethanol Extract ofLeaf Contributes to the Amelioration of Dexamethasone-Induced Muscle Atrophy. Abstract:  Muscle atrophy is characterized by a decline in muscle mass and function. Excessive glucocorticoids in the body due to aging or drug treatment can promote muscle wasting. In this study, we investigated the preventive effect ofleaf (NNL) ethanolic extract on muscle atrophy induced by dexamethasone (DEX), a synthetic glucocorticoid, in mice and its underlying mechanisms. The administration of NNL extract increased weight, cross-sectional area, and grip strength of quadriceps (QD) and gastrocnemius (GA) muscles in DEX-induced muscle atrophy in mice. The NNL extract administration decreased the expression of muscle atrophic factors, such as muscle RING-finger protein-1 and atrogin-1, and autophagy factors, such as Beclin-1, microtubule-associated protein 1A/1B-light chain 3 (LC3-I/II), and sequestosome 1 (p62/SQSTM1) in DEX-injected mice. DEX injection increased the protein expression levels of NOD-like receptor pyrin domain-containing protein 3 (NLRP3), cleaved-caspase-1, interleukin-1beta (IL-1), and cleaved-gasdermin D (GSDMD), which were significantly reduced by NNL extract administration (500 mg/kg/day). In vitro studies using C2C12 myotubes also revealed that NNL extract treatment inhibited the DEX-induced increase in autophagy factors, pyroptosis-related factors, and NF-B. Overall, the NNL extract prevented DEX-induced muscle atrophy by downregulating the ubiquitin-proteasome system, autophagy pathway, and GSDMD-mediated pyroptosis pathway, which are involved in muscle degradation.

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A crypto insurance provider will typically assess at least 2,000 variables across 20 risk areas before they even consider insuring a platform, according to an insurance executive.

agoodcartoon:

there isnt an lol big enough

powerful image

PMID:  J Zhejiang Univ Sci B. 2023 Feb 15 ;24(2):185-190. PMID: 36751703 Abstract Title:  Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model. Abstract:  Sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure, particularly spleen dysfunction. In 2017, the worldwide incidence was 48.9 million sepsis cases and 11 million sepsis-related deaths were reported (Rudd et al., 2020). Inflammation, oxidative stress, and apoptosis are the most common pathologies seen in sepsis. Liensinine (LIE) is a bisbenzylisoquinoline-type alkaloid extracted from the seed embryo of Nelumbo nucifera. Lotus seed hearts have high content of LIE which mainly has antihypertensive and antiarrhythmic pharmacological effects. It can exert anti-carcinogenic activity by regulating cell, inflammation, and apoptosis signaling pathways (Manogaran et al., 2019). However, its protective effect from sepsis-induced spleen damage is unknown. In this research, we established a mouse sepsis model induced by lipopolysaccharide (LPS) and investigated the protective effects of LIE on sepsis spleen injury in terms of inflammatory response, oxidative stress, and apoptosis.

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PMID:  Front Nutr. 2022 ;9:1111283. Epub 2023 Jan 11. PMID: 36712522 Abstract Title:  The mitigative effect of lotus root () extract on acute alcoholism through activation of alcohol catabolic enzyme, reduction of oxidative stress, and protection of liver function. Abstract:  OBJECTIVES: Lotus root () is a common medicinal-food dual-use vegetable. In this study, the effects of lotus root extract on acute alcoholism were investigated.METHODS: The Walle-Hoch method was used to determine the ADH activity of lotus root extracts. Lotus root methanol extract were identified by UPLC-QTOF-MS/MS based metabolomics analysis. Then 109 active ingredients with achievable oral doses and drug-like properties were explored using the TCMSP platform. SwissTargetPrediction Database to predict lotus root treatment targets for acute alcoholismSTRING database (https://www.string-db.org/) was used to construct protein-protein interaction network graphs. Gene ontology (GO) functional, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of genes common to lotus root and alcoholism by Metascap database. Molecular docking simulations were performed using AutoDock 1.5.6 software. Animal experiments verified the relieving effect of lotus root extract on acute alcoholism after intervention.RESULTS: Results indicated the methanol extract of lotus root showed the highest activation rate of ethanol dehydrogenase(18.87%). The 433 compounds of lotus root methanol extract were identified by UPLC-QTOF-MS/MS based metabolomics analysis. Bioinformatics analysis indicate that there were 224 intersectioning targets between lotus root extract and acute alcoholism. KEGG enrichment analysised shows that lotus root extract may play a role in treating acute alcoholism by intervening with the neuroactive ligand-receptor interaction pathway. The protein-protein interaction network (PPI) analysis found that HSP90AA1, MAPK1 and STAT3 played a key role in lotus root extract-modulated PPI networks. Molecular docking showed that (7R, 8S)-dihydrodihydrodipine cypressol had the best binding ability with MAPK1. Experiments in mice indicate that lotus root extract improved the activity of liver alcohol dehydrogenase (ADH), acetaldehyde dehydrogenase (ALDH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), increase glutathione (GSH) and reduce malondialdehyde (MDA) levels, decrease glutamate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (AKP) in the serum of mice with acute alcoholism, and accelerate the metabolic rate of alcohol after drinking. This study reveals the mechanism of lotus root to alleviate acute alcoholism, which provides a basis for further research on functional foods using lotus root and offers new possibilities for the treatment of acute alcohol...

The cards pictured are from the Crowley Thoth Tarot Deck.

Queen of Wands and The Moon

This week, we enter the month of June and have a Sagiartius Full Moon on June 3rd. The cards guide us and call our best selevs forward as we journey through the days ahead.

Our first card this week is the Queen of Wands. She is the fire inside all of us. She is the energy that makes us loving and loyal friends and worthy adversaries.

The Queen speaks to the passionate energy that bubbles up when we see injustices in the world. And the warrior in us that has been through the very worst of days and made it out stronger.

This makes her tough and opinionated but lacking when it comes to communicating in a diplomatic way. She can be overpowering and turn people off with her intensity.

As we journey through Gemini Season, it is even more important we are aware of how we communicate, as it can make it even more challenging. We should use the lessons of the Queen of Wands to practice compassionate expression.

This week we are called to connect to our fire within while learning to be aware of how this fire might impact others. Some questions we might ask are:

How can we be both strong and warm at the same time? How can we share our passion without alienating others? How can we have compassion for those we disagree with while still holding them accountable?

Let the fire push you to create change through understanding and grace. The kindness in your communication and actions will make them so much more impactful.

Our next card this week is The Moon. The Moon is number eighteen in the Major Arcana and depicts a mysterious night-time scene. The card here shows Anubis, the jackal god of the Egyptians. Below is a scarab beetle holding a glowing moon.

The scarab is is a symbol of renewal and immortality, portaying the Moons association with natural cycles and rhythms. We are called to tap into the cycles and rhythms of our lives and to allow ourselves to go with the flow.

When we resist the natural ups and downs, we find ourselves exhausted and out of sync. But when we accept that everything has both peaks and valleys, we are able to feel more grounded and at peace.

We know that after winter there is always spring. And that all New Moons will lead into a Full Moon and back again. It is the same with our lives. There are times of plenty and times with less. The more comfortable we are with the cyclical nature of life the more we can find the good in each moment.

The Moon card indicates a voyage to the centre of ourselves. When we journey inside, we dont find flaws or weaknesses, but an unshakeable core that is steady through all the phases of life.

When we connect to ourlseves through the Moons guidance, we find our psychic and intuitive abiliti...

PMID:  J Agric Food Chem. 2023 Jan 11 ;71(1):443-456. Epub 2022 Dec 27. PMID: 36573646 Abstract Title:  Nuciferine Ameliorates Nonesterified Fatty Acid-Induced Bovine Mammary Epithelial Cell Lipid Accumulation, Apoptosis, and Impaired Migration via Activating LKB1/AMPK Signaling Pathway. Abstract:  High blood concentrations of nonesterified fatty acids (NEFAs) provoke various metabolic disorders and are associated with mammary tissue injury and decreased milk production in dairy cows. Nuciferine, an alkaloid found inleaves, has great potential for correcting lipid metabolism derangements and lipotoxicity. In this study, we evaluated the lipotoxicity induced by excessive NEFA in bovine mammary epithelial cells (bMECs) and investigated whether nuciferine alleviates NEFA-induced lipotoxicity and the underlying molecular mechanisms. We found that excessive NEFA (1.2 and 2.4 mM) induced lipid accumulation, apoptosis, and migration ability impairment in bMECs, whereas nuciferine could ameliorate these disarrangements, as indicated by decreasing triglyceride content, protein abundance of SREBP-1c, cytoplasmic cytochrome, and cleaved caspase-3 and increasing protein abundance of PPARand migration ability. Moreover, nuciferine could reverse NEFA-induced LKB1/AMPK signaling inhibition, and the protective effect of nuciferine on lipotoxicity caused by NEFA was abrogated by AMPK inhibitor dorsomorphin. Furthermore, transfection with LKB1 siRNA (si-LKB1) largely abolished the activation effect of nuciferine on AMPK. Overall, nuciferine can protect bMECs from excessive NEFA-induced lipid accumulation, apoptosis, and impaired migration by activating LKB1/AMPK signaling pathway.

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PMID:  Heliyon. 2023 Feb ;9(2):e13630. Epub 2023 Feb 11. PMID: 36865453 Abstract Title:  Nuciferine improves cardiac function in mice subjected to myocardial ischemia/reperfusion injury by upregulating PPAR-. Abstract:  Ischemic heart disease and myocardial infarction contribute to the leading cause of death in worldwide. The prevention and management of myocardial ischemia/reperfusion (I/R) injury is an essential part of coronary heart disease surgery and is becoming a major clinical problem in the treatment of ischemic heart disease. Nuciferine has potent anti-inflammatory and antioxidative stress effects, but its role in myocardial ischemia-reperfusion (I/R) is unclear. In this study, we found that nuciferine could reduce the myocardial infarct size in a mouse myocardial ischemia-reperfusion model and improve cardiac function. Furthermore, nuciferine could effectively inhibit hypoxia and reoxygenation (H/R) stimulated apoptosis of primary mouse cardiomyocytes. In addition, nuciferine significantly reduced the level of oxidative stress. The peroxisome proliferator-activated receptor gamma (PPAR-) inhibitor GW9662 could reverse the protective effect of nuciferine on cardiomyocytes. These results indicate that nuciferine can inhibit the apoptosis of cardiomyocytes by upregulating PPAR-and reducing the I/R-induced myocardial injury in mice.

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PMID:  Int Immunopharmacol. 2023 Feb ;115:109613. Epub 2022 Dec 26. PMID: 36577154 Abstract Title:  Nuciferine alleviates intestinal inflammation by inhibiting MAPK/NF-B and NLRP3/Caspase 1 pathways in vivo and in vitro. Abstract:  Nuciferine (NCF) is an aporphine alkaloid and a principal bioactive constituent in the lotus plant. Herewith, we investigated the potential anti-inflammatory effect and underlying mechanisms of NCF employing dextran sulfate sodium (DSS)-induced ulcerative colitis in mice, a predominant intestinal inflammatory disease, and mouse RAW 264.7 cells in vitro. Lipopolysaccharide (LPS) was used to generate an inflammatory response in the RAW 264.7 cells. The disease activity index (DAI), colon morphology, colonoscopy, and colon histopathology were performed to assess experimental colitis. The biochemical assays, enzyme-linked immunosorbent assay (ELISA), and immunoblot analysis were performed to understand the underlying mechanisms. In RAW 264.7 cells, NCF pretreatment significantly decreased the expression of inducible nitric oxide synthase (iNOS), the expression and release of pro-inflammatory cytokines including interleukin (IL)-1, IL-18, and tumor necrosis factor-(TNF-) and interfered with the activation of mitogen-activated protein kinase (MAPK), nuclear factor-B (NF-B), and NOD-like family pyrin domain containing 3 (NLRP3) signaling pathways. The oral treatment of NCF substantially alleviated the DSS-induced DAI, increased colon length, and restored colon morphology and histology. Compared to the DSS-induced mice, the proteins involved in the activation of MAPK/NF-B/NLRP3 pathways and the cytokines were markedly decreased in the NCF-treated mice. Moreover, the tight junction architecture of the colon was well-maintained in NCF treatment groups by regulating the expression of claudin-1 and zonula occludens-1 (ZO-1) proteins. All these findings suggest that NCF can be a promising molecule to modulate ulcerative colitis.

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wrong turn

The size of one of the suns sunspots has increased to the point that it can be seen from Earth without the need of magnification; nevertheless, eye protection is still clearly recommended while viewing it.

It is no longer necessary to use a telescope in order to see sunspot AR3310 from Earth since its size has increased to the point where it is now visible with the naked eye. An image of the sunspot, with a little Earth superimposed on it, was released on the internet by a South Korean astronomer by the name of Bum-Suk Yeom.

Naked-Eye Sunspot using Solar Glasses (or Solar Filter), Yeom said in an Instagram post sharing the image. A giant sunspot, visible to the naked eye, is crossing the suns disk. A [sunspot] can be seen to the left of the center of the solar disk.

Sunspots are patches of darkness that appear on the surface of the sun and are created by concentrations of magnetic fields that are exceptionally strong and twisted. If these fields are strong enough, they prevent part of the heat from the suns core from reaching its atmosphere, which results in the surface of the sun being colder and seeming darker than normal.

Sometimes sunspots are big enough that they may be seen with the naked eye, however you should still use eye protection since the suns glare can be rather intense.

The minimal visibility threshold is estimated as [roughly] 425 millionths of the visible solar disk0.04 percent of the solar diskwhereas larger sunspot area and favorable meteorological conditions improve their visibility, Hisashi Hayakawa, a solar physicist at Japans Nagoya University told Newsweek.

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